Craig M. Crews, Ph.D.
Dr. Crews is the Founder and Chief Scientific Advisor of Arvinas, as well as the L.B. Cullman Professor of Molecular, Cellular and Developmental Biology, Chemistry and Pharmacology at Yale University.
Dr. Crews’ research focuses on the design, syntheses and evaluation of small molecule regulators of intracellular protein levels and their development as novel therapeutics. YU101, a novel proteasome inhibitor from his lab, served as the lead asset of Proteolix, Inc. (purchased by Onyx in 2009; acquired by Amgen, 2013) and became carfilzomib/Kyprolis™ which received FDA approval for relapsed/refractory multiple myeloma in 2012.
Scott Biller, Ph.D.
Dr. Biller joined Agios as Chief Scientific Officer in September 2010, with more than 25 years of drug discovery and development experience. From 2003 to September 2010, he was Vice President and Head of Global Discovery Chemistry at the Novartis Institutes for Biomedical Research. Prior to Novartis, Dr. Biller held the positions of Vice President, Pharmaceutical Candidate Optimization at the Bristol Myers Squibb (BMS) Pharmaceutical Research Institute and Executive Director of Drug Discovery Chemistry for the BMS research site in Lawrenceville, N.J. Among his other key leadership positions at BMS, Dr. Biller was the Executive Director of Metabolic Diseases Chemistry.
Dr. Biller contributed to robust pipelines at both BMS and Novartis, culminating in two medicines launched worldwide (Onglyza® for the treatment of Type 2 diabetes and Juxtapid® for familial hypercholesterolemia) and three additional drugs reaching Phase 3 clinical development.
Dr. Biller earned a B.S. in Chemistry at MIT, a Ph.D. in Organic Chemistry at Caltech and was an NIH Postdoctoral Fellow at Columbia University in Natural Product Synthesis.
Peter Farina, Ph.D.
Dr. Farina is an Executive in Residence at Canaan Partners, a venture capital firm where he assesses and advises on pharmaceutical, biotechnology and healthcare investments. He is also the Managing Partner of Salient Science & Technology, LLC, a consulting firm which advises several U.S. and Chinese biotech firms on strategic and technical matters in pharmaceutical R&D. Dr. Farina currently serves as the Co-Chair and Board Member of the Connecticut United for Research Excellence (CURE) organization, and is on the Advisory Board of the University of Connecticut School of Pharmacy. He is also a member of the NIH Blueprint Neurotherapeutics Network steering committee, the Emory University DRIVE Advisory Board, and was a Founder and CEO of Developing World Cures, a nonprofit company working on neglected diseases.
Dr. Farina retired in 2008 as Senior Vice President of Development at Boehringer Ingelheim Pharmaceuticals, where he was responsible for North American development of drugs in the therapeutic areas of immunology/inflammation, virology and cardiovascular disease. During his tenure, his interdisciplinary team worked on the development and successful registration of Aptivus®, an HIV protease inhibitor, Viramune XR® for HIV, and Atrovent HFA® for COPD and emphysema. Prior to this position, he served as Vice President of Research at the Ridgefield Center. He has also held positions as the Director of Inflammatory Diseases and Director of Biochemistry over his 28-year career with Boehringer Ingelheim. Prior to joining BI, he spent six years in the Corporate Research Laboratories and Medical Products Division of Union Carbide Corporation, where he did research and development of immunodiagnostics.
Dr. Farina has a Ph.D. in Organic Chemistry from SUNY Buffalo and did postdoctoral work in Bioorganic Chemistry at Pennsylvania State University with Dr. Stephen Benkovic.
Thomas J. Lynch, Jr., M.D.
Dr. Lynch has served as the Chairman and Chief Executive Officer of Massachusetts General Physicians Organization since 2015. He has also served as a member of the Massachusetts General Hospital Board since 2015. Previously, he served as the Director of Yale Cancer Center and was the Richard and Jonathan Sackler Professor of Internal Medicine, Yale Cancer Center, Yale School of Medicine from 2009 to 2015, during which time he also served as the Physician-in-Chief of Smilow Cancer Hospital at Yale New Haven. Prior to 2009, Dr. Lynch served as Professor of Medicine at Harvard Medical School and Chief of Hematology/Oncology at Massachusetts General Hospital. He helped found the Boston-based Kenneth B. Schwartz Center for the Promotion of Caregiver/Patient Relations and became Vice Chair of its Board of Directors in 2006.
Dr. Lynch is an expert in the treatment of lung cancer with a special interest in personalized medicine. He has made important contributions in developmental therapeutics and in defining the optimal treatment for patients with lung cancer, pioneering the use of molecular testing for mutations in the epidermal growth factor receptor gene to select patients who can benefit from targeted lung cancer therapies. Dr. Lynch is the author of numerous publications and maintains a vigorous clinical practice.
Dr. Lynch received his undergraduate degree from Yale College and his M.D. from Yale School of Medicine. He completed his internship and residency at MGH, and after serving a fellowship in medical oncology at the Dana-Farber Cancer Institute, he joined the medical staff at the Massachusetts General Hospital.
Briggs Morrison, M.D.
Dr. Morrison currently serves as a managing director of MPM Capital, a healthcare-focused venture capital firm, since June 2015. Prior to joining MPM, he served as Executive Vice President, Global Medicines Development and Chief Medical Officer at AstraZeneca plc, a publicly traded company, from January 2012 to June 2015, leading the company’s global, late-stage development organization and serving as a member of the AstraZeneca senior executive team. He previously held a number of positions at Pfizer Inc., a publicly traded company, from 2007 to January 2012 that culminated in his appointment as Head, Medical Affairs, Safety and Regulatory Affairs for Pfizer’s human health business, and also served in roles of increasing responsibility at Merck Research Laboratories, a division of Merck & Co., Inc., from 1995 to 2007, ascending to the role of Vice President, Clinical Sciences, Oncology, responsible for clinical development of all novel anti-cancer drugs. Dr. Morrison was chairman of the board of TransCelerate BioPharma Inc., an industry-funded company charged with improving aspects of clinical trials, from 2014 to 2015, a member of the executive committee of the Clinical Trials Transformation Initiative (CTTI) sponsored by FDA, and is on the board of ACRES (Alliance for Clinical Research Excellence and Safety). Dr. Morrison received a B.S. in biology from Georgetown University and an M.D. from the University of Connecticut.
Mark Murcko, Ph.D.
Dr. Murcko, Principal at Disruptive Biomedical, LLC is an independent consultant and Professor of Practice at both MIT and Northeastern. Until November 2011, he was Chief Technology Officer and Chair of the Scientific Advisory Board of Vertex Pharmaceuticals. In this role, he was responsible for the identification, validation and incorporation of disruptive technologies across global R&D. Dr. Murcko is a co-inventor of Incivek™ (telaprevir), the world’s most widely prescribed HCV protease inhibitor; as well as Agenerase™ (amprenavir) and Lexiva™ (fosamprenavir), Vertex’s two marketed drugs for HIV. In addition, he guided the early efforts of Vertex’s cystic fibrosis program that produced the marketed drug Kalydeco™ (ivacaftor), and several other compounds currently in late stage development.
Dr. Murcko is also a co-inventor of eight other clinical candidates in the areas of cancer, inflammation/immunology and infectious disease. Prior to Vertex, Dr. Murcko worked at Merck Sharp & Dohme. He has served on the editorial boards of many scientific publications, was the co-organizer of the 2008 ACS National Medicinal Chemistry Symposium, and served as Chair of the 2013 Gordon Research Conference in Medicinal Chemistry. He is a co-inventor on more than 45 issued patents, has co-authored more than 85 scientific articles, and has delivered more than 130 invited lectures.
Richard, J. Ulevitch, Ph.D.
Dr. Ulevitch is a Venture Partner at 5AM Ventures. Previously, he was Professor and Chairman of the Department of Immunology at The Scripps Research Institute, where he remains as Professor and Chairman Emeritus. For nearly three decades, Dr. Ulevitch has performed research to understand the role of the immune system in human disease.
He serves as a Scientific Advisor to Aravis Ventures, a European life science venture capital fund and previously served as an advisor to the Lombard Odier Immunology Fund, where he evaluated numerous biotechnology companies over a 15-year span. Dr. Ulevitch serves on the Scientific Advisory Board of Cleave Biosciences, Igenica Biotherapeutics, Pulmatrix and RuiYi (previously Anaphore). He was also formerly a member of the Scientific Advisory Boards at Envoy (acquired by Takeda) and Ikaria.
Dr. Ulevitch received an A.B. from Washington and Jefferson College and a Ph.D. in Biochemistry from the University of Pennsylvania.
Daniel D. Von Hoff, M.D., F.A.C.P.
Dr. Von Hoff is currently Physician-in-Chief, Distinguished Professor and Director of Clinical Translational Research Division at TGen (Translational Genomics Research Institute) in Phoenix, AZ. He is also Chief Scientific Officer for US Oncology Network and Scottsdale Healthcare’s Clinical Research Institute. He holds an appointment as Professor of Medicine at the Mayo Clinic in Scottsdale, AZ.
Dr. Von Hoff and his colleagues were involved in the beginning of the development of many of the anti-neoplastic agents including: mitoxantrone, fludarabine, paclitaxel, docetaxel, gemcitabine, irinotecan, nelarabine, capecitabine, lapatinib and others. Dr. Von Hoff has published more than 620 papers, 137 book chapters and over 1050 abstracts. Dr. Von Hoff received the 2010 David A. Karnofsky Memorial Award from the American Society of Clinical Oncology for his outstanding contributions to cancer research leading to significant improvement in patient care. Dr. Von Hoff was appointed to President Bush’s National Cancer Advisory Board in 2004-2010.
Dr. Von Hoff is the past President of the American Association for Cancer Research (the world’s largest cancer research organization), a Fellow of the American College of Physicians, and a member and past board member of the American Society of Clinical Oncology. He is a founder of ILEX™ Oncology, Inc. (acquired by Genzyme). Dr. Von Hoff is the Founder and Editor Emeritus of Investigational New Drugs–The Journal of New Anticancer Agents, and Editor-in-Chief of Molecular Cancer Therapeutics. He is a Co-Founder of the AACR/ASCO Methods in Clinical Cancer Research Workshop.