Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Research Associate (Biology)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health.

Education and Training

  • BS with a degree in the biological sciences with some relevant laboratory experience preferred

Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious with an ability to multi-task
  • Emphasizes quality work product
  • Experience in standard laboratory techniques, eg pipetting, aseptic cell culture
  • Demonstrated ability to follow simple laboratory protocols independently and accurately, including troubleshooting
  • Familiarity with Microsoft Office software or the equivalent

Job Responsibilities

  • Operation of the robotics and software used for diluting large numbers of compounds for dose response analysis
  • Assist with Lab Management and Logistics, eg lab supply receiving, common-use reagent preparation
  • Learn multiple assay platforms for measuring ligand/protein and protein/protein interactions
  • Learn techniques involved in analyzing proteins inside cells
  • Learn how to do protein expression and purification

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

Associate Directory/Director of Regulatory Affairs

Arvinas Inc, New Haven, CT

The remit of this role will include identification of optimal product development strategy, filing of high-quality regulatory submissions, maintenance of regulatory dossiers, and coordinating the interaction with regulatory agencies in relation to submissions and other relevant topics. This role is perfect for a multi-tasker who is at their best in a diverse, cross-functional working environment.

Responsibilities

  • Tracking and review of documents, as they are prepared for submission to health authorities
  • Work with regulatory operations specialists to prepare and file high-quality submissions for regulatory authorities.
  • Identify optimal product development strategy
  • Coordinate interaction with regulatory agencies. Lead clinical and non-clinical agency correspondence and regulatory applications (IND and CTA, as needed) to support clinical development activities.
  • Serve as regulatory representative on cross-functional teams
  • Make regulatory decisions in regard to submission acceptability
  • Review technical documents for relevant compliance adherence, and identification of data gaps/needs
  • Effectively communicate with individuals at all levels of the organization
  • Offer training/coaching regarding compliance
  • Develop quality standards for regulatory affairs
  • All ad-hoc duties as assigned

Skills and Qualifications

  • BA in a scientific discipline, with a minimum of 10 years of applicable and relevant experience, or MA in a scientific discipline with a 5-years of applicable and relevant experience
  • Successful track record of preparing and filing relevant regulatory documentation
  • Thorough understanding of the relevant regulations and guidelines
  • Ability to effectively organize and prioritize tasks to achieve established deadlines
  • Excellent written, verbal, and interpersonal communication skills
  • Experience in oncology/rare diseases preferred

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Head of Preclinical Sciences

The Head of Preclinical Sciences is responsible for overseeing the drug metabolism, pharmacokinetics and toxicology support for development candidate nomination and IND filings. Qualified candidates will be creative and detail-oriented with a passion for drug discovery, possess excellent project management, time management, communication, data analysis, and interpersonal skills, along with an overall understanding of, and direct hands on experience, in early-stage development within the biotech/biopharma industry.  This position will report to the Vice President, Biology.

Activities include, but are not limited to:

  • Collaborate with research project leaders to develop project-specific strategies to generate appropriate data to support development candidate nomination and IND filing
  • Oversee the design and management of pre-clinical studies (GLP and non-GLP) for inclusion in IND submissions, including ADME/PK and biodistribution and toxicology
  • Oversee the selection and management of consultants and contract research organizations (CROs) to support pre-clinical development programs
  • Manage projects conducted by CROs with efficient governance including contract execution, authorization of study amendments, schedule and budget variance management, progress reporting to stakeholders, review of data and draft study reports, completion of contract milestones, study close-out and alignment of preclinical development efforts with corporate drug development efforts and priorities
  • Write and edit pre-clinical study reports
  • Oversee drafting of the relevant sections and individual reports to support regulatory filing including pre-IND, IND, IB, and clinical lab manuals
  • Participate in discussions with FDA to obtain feedback on pre-clinical development programs
  • Contribute to clinical development plans
  • Ensure compliance with global pre-clinical studies regulatory guidelines

 

Basic Qualifications:

  • PhD or DVM and post-doctoral experience in Pharmacology, Drug Metabolism, Toxicology or Pathology and knowledge of biochemistry, cell biology, systems biology, and physiology.
  • Solid understanding of the drug discovery and development process based on at least 7-10 years of relevant experience in the biotech/pharmaceutical industry
  • Demonstrable contributions to regulatory filings and working knowledge of GLP, GCP and ICH regulations
  • Experience with the design and execution of in vitro/in vivo experiments to determine the effects of therapeutics on biological systems, with line of sight to human safety risk understanding.
  • Hands-on experience with in vitro toxicology, pharmacology and/or molecular biology experimentation to investigate molecular mechanisms of drug action.
  • Strong leadership competencies and management experience, including selecting CROs and overseeing the relationship.
  • Excellent written and oral communication, presentation and influencing skills Highly motivated, creative, innovative, reliable scientist, with a flexible, collaborative, team-oriented mindset, who solves problems in a goal-focused fashion and can excel in a fast-paced small company environment
  • A social personality that contributes to an open, positive, collaborative working climate.

 

Preferred Qualifications:

  • DABT certification and experience as GLP Study Director is preferred, but not required.
  • Working knowledge of human dose modeling

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Early Development Team Leader

Essential Functions

The successful candidate will have a proven track record in effectively leading drug development teams as well as a strong scientific and/or clinical background in oncology.

 

  • Develop the overall program vision including scientific, clinical, and pre-commercial strategies and plans through registration and commercialization
  • Lead the strategic planning, decision-making, and risk assessment processes to deliver quality outcomes
  • Ensures rigorous scientific debate and robust data quality through effectively gathering team, subject matter, and cross functional feedback
  • Possess a basic understanding of all functions represented on the team in order to ask probing questions and assess risk
  • Ensure cross-functional alignment within the project team and with corporate/Management Team strategy, proactively communicate throughout all phases of program strategy and execution
  • Hold team accountable for deliverables and timelines within agreed upon budget; instill appropriate sense of urgency
  • Hold decision rights and advance program to its next agreed upon milestones through data-driven decisions
  • Work creatively to find solutions to problems and overcome obstacles
  • Manage all aspects of program timelines and deliverables, anticipate risks and proactively communicate potential impacts and mitigation plans to the Management Team
  • Incorporate external information (e.g. from scientific meetings, competitive intelligence) into program planning, adjusting plans as necessary to meet corporate objectives.
  • Ability to manage multiple complex programs at the same time, in a rapidly changing environment, while ensuring high transparency
  • Represent the program to executive stakeholders including the Board of Directors

Education & Experience Requirements

  • M.D. or PhD. Experience in small and large pharma
    •12+ years’ industry experience, with deep experience managing nonclinical and clinical in pharmaceutical or biotech company
    • Experience of drug development in oncology required
    • Strong knowledge and understanding of regulatory requirements for product approval
    • Aware of changing trends in pharmaceutical drug development, and experience in applying new approaches
    • Extensive team leadership in a matrix and virtual environment
    • Experience with drugs at all stages of Clinical Development and presenting data to regulatory agencies/Advisory Committees.
    • Experience as an effective mentor. Line management experience highly preferred.
    • Strong publication record and experience with external Scientific Advisory Boards preferred.

Key Skills and Competencies

  • Ability to work cooperatively within a cross-functional, partially virtual team setting, is critical
  • Outstanding interpersonal communication skills
  • Effectively lead a cross-functional team in a virtual and/or matrix organizational structure.
  • High-level analytical skills, especially with regard to understanding and interpreting scientific research and literature are essential.
  • Ability to identify, analyze and adjust work procedures for maximum efficiency and be able to meet tight deadlines.
  • Working knowledge of effective development strategies in oncology and a broad understanding of clinical product development in the pharmaceutical industry.

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Director, Clinical Operations

Arvinas is seeking an experienced Director of Clinical Operations; this person will lead and build a team of Clinical Operations professionals who will oversee the strategy for implementation and the execution of all sponsored clinical trials within Arvinas’ development pipeline.

The Director should have experience driving a pre-clinical study into Phase I and through clinical development. The Director will also ensure that clinical stage programs achieve program objectives within established timelines, budget and quality standards. Working with the company leadership, the individual will ensure that the appropriate company infrastructure and quality systems are in place to support all clinical trials. In this role, she/he will lead the execution of the clinical studies in conformance with Good Clinical Practices (GCP), International Conference of Harmonization (ICH) Guidelines and Arvinas SOPs. The Director will report to the VP of Development Operations at Arvinas’ headquarters in New Haven, CT.

Key Responsibilities:

  • Leads and directs the clinical operations team responsible for management and execution of all clinical trials. This includes but is not limited to, ensuring cost, quality and timeliness of multiple programs is met.
  • Responsible for creating/maintaining clinical operation department goals, budget, training matrix, and study priorities.
  • Provides strategic and technical guidance to ensure that clinical trials are properly defined, planned and executed.
  • Working in a matrix organization, ensures that study objectives are in line with the clinical development strategy and the overall corporate goals.
  • Leads and directs the building of department infrastructure, including developing, training, and retaining the clinical operations team; ensures prioritization of activities and resourcing is in line with clinical development programs.
  • Ensures that external vendors are selected and managed to deliver within established timelines and budget. This also includes site qualification and initiation.
  • Drives the creation of clinical operations Standard Operating Procedures (SOPs), systems, and processes across the trials; ensures compliance with regulatory and other applicable standards and guidelines.
  • Builds collaborative relationships with key stakeholders including Medical, Regulatory Affairs, CMC/Supply Chain, IT, Legal, Finance departments, and project teams as needed to support clinical programs.
  • Collaborate with KOLs for feedback on study protocols and development plans.
  • Implement and lead a Clinical Development Team
  • Fosters a highly collaborative culture and serves as a leadership role model within the company and with external stakeholders.

Qualifications:

  • Bachelor’s degree in Life Sciences or Pharmacy. Advanced degree preferred.
  • 12+ years of strong hands-on experience leading clinical trials execution.
  • Minimum 5 years in supervisory role managing clinical operations staff.
  • Ability to take a leadership role, motivate staff, and drive high quality execution.
  • Oncology/rare disease experience preferred or multi-therapeutic clinical operations experience
  • Experience managing a study from pre-clinical to clinical phase.
  • Proven ability to build strong relationships with external partners, CROs, and vendors including extensive experience managing contracts and clinical finance activities.
  • Ability to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
  • Effective communication and interpersonal skills; effective interaction with senior management
  • Flexibility to travel as required

Special Knowledge Preferred:

  • Experience with Investigational New Drug applications (INDs).
  • Medical writing experience.
  • Proficiency with Microsoft Office SystemsArvinas is seeking an experienced Director of Clinical Operations; this person will lead and build a team of Clinical Operations professionals who will oversee the strategy for implementation and the execution of all sponsored clinical trials within Arvinas’ development pipeline.The Director should have experience driving a pre-clinical study into Phase I and through clinical development. The Director will also ensure that clinical stage programs achieve program objectives within established timelines, budget and quality standards. Working with the company leadership, the individual will ensure that the appropriate company infrastructure and quality systems are in place to support all clinical trials. In this role, she/he will lead the execution of the clinical studies in conformance with Good Clinical Practices (GCP), International Conference of Harmonization (ICH) Guidelines and Arvinas SOPs. The Director will report to the VP of Development Operations at Arvinas’ headquarters in New Haven, CT.

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Research Scientist/Sr. Research Scientist (Biology) (3)

Arvinas, a new start-up company based in New Haven, CT, is seeking innovative, collaborative and experienced biologists with expertise in cancer biology to investigate oncology biology as well as to develop novel, targeted therapeutics that address critical therapeutic targets to benefit patients suffering from cancer. Knowledge of the underpinnings of cancer therapeutic approaches is preferred but not essential. These positions require facility in working across disciplines to integrate the efforts of a project team to drive the discovery of novel small molecule therapeutics & deliver them for clinical testing.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential

Requirements

  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

Associate Scientist / Sr. Associate Scientist (Biology) (9)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.