Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Biology

Research Associate Platform Biology (Biophysics)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

We are looking for a scientist to strengthen our biophysics team. This position will directly use biophysical and biochemical methods to characterize the binding of ligands for transformation into PROTACs. This position will provide the key, critical data necessary to drive programs toward targeted degradation.

This position reports to the Senior Associate Scientist in our Platform Biology group and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Utilization of assay design techniques, quality control and execution of medium- to high- throughput 96/384 well assay formats, such as SPR, MST, AlphaLISA, quantitative Bioluminescent/ Fluorescence assays, and other biophysical/biochemical approaches
  • Incumbent will also learn how to apply biophysical techniques to PROTAC discovery through determination of binding affinities, binding kinetics and protein-protein interactions
  • Leverage and think about principles behind multiple assay platforms for measuring target engagement, biophysical approaches including SPR, MST, TR-FRET, AlphaLISA, and apply them to the ubiquitin-proteasome system and targeted protein degradation
  • Apply excellent organizational and prioritization skills; demonstrate accomplished biologic and biochemical academic record with laboratory experience.  Analyze data using strong background in quantitative sciences.
  • Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs.  Troubleshoot through technical and scientific challenges in order to deliver critical data.
  • Organize experimental results to be shared with project teams; openly communicate with chemistry; maintain clear experimental records.

 

Qualifications

  • A strong work ethic and willingness to learn drug discovery approaches and biochemical and biophysical techniques, is a requirement. Strong theoretical knowledge in biophysics and biochemistry is a plus.
  • Knowledge and theory behind protein expression, recombinant protein expression would be a plus
  • Experience with Microsoft Excel, Prism, etc.

 

Education

  • BS/MS with strong interest in contributing to the discovery of PROTAC molecules with drug-like properties in an innovative Pharma/Biotech environment.  Training in biophysical techniques is a plus and will be provided as needed.

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

(Senior) Director, Neurobiology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Education and Training

  • Ph.D, with 10+ years of industry/ biotech leadership experience in neurobiology and pharmacology with clear contributions to clinical candidates.

Requirements

  • Track record of innovation in the discovery of translational biomarkers of therapeutics for Tauopathies, Parkinson’s Disease and other neurodegenerative diseases.
  • Established scientific reputation and statistical rigor in the study of neurodegeneration as evidenced by strong publication record, relationships with key opinion leaders and effective leader of external science and collaborations.
  • Demonstrated ability to lead, recruit, mentor, develop and motivate a team of creative, experienced scientists.
  • Strong team leader who guides cross functional scientists to build deep mechanistic and pharmacologic relationships including target engagement and function in human and rodent neuronal systems, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples.
  • Communicates effectively with employees, colleagues, leadership teams and the broader external neuroscience community as evidenced by publications, presentations, inventions and contributions to clinical candidates for regulatory filings.
  • Contributions to biomarker plans and pharmacodynamic biomarker assay development. Deep track record of contributions to IND documentation.
  • Confident self-starter with a strong work ethic

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer  

Director/Senior Director, Immunology/Immuno-oncology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will develop and integrate a research strategy, and build a team, to apply the PROTAC technology in the areas of immunology/immuno-oncology.  This highly motivated individual must have a solid working knowledge of innate and adaptive immune cell biology and tumor/immune cell interactions.  You will ensure the progression of projects from concept to clinical testing, focusing on developing PROTACs with a strong translational rationale. This scientific leader will maintain a connection to the appropriate research communities, establishing and managing productive collaborations with external scientists to help drive innovation.  This position reports to the Chief Scientific Officer and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

  • Identify and validate targets using a variety of tools, including human immunology, human genetics, human sample analyses, bioinformatics, clinical data, and preclinical in vitro and in vivo models
  • Develop assays to profile compounds using target engagement, mechanistic and functional readouts in the appropriate in vitro and in vivo model systems to support structure-activity relationships that guide lead identification, optimization and development candidate selection
  • Implement new models and technologies to incorporate into drug discovery and advance portfolio projects
  • Build and work on cross-disciplinary, drug discovery project teams; integrating and evaluating the work of multiple drug discovery functions.
  • Build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Incorporate knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Recruit, retain, and develop world-class scientific talent.
  • Lead and participate on cross-disciplinary, drug discovery project teams; integrate and evaluate the work of multiple drug discovery groups / functions to determine optimal solutions to discovery challenges.
  • Educate, support, coach, mentor, motivate, and grow scientists who are developing expertise in immuno-oncology, in either a supervisory or matrix leadership capacity.

Qualifications

  • Deep expertise and outstanding record of research and publications in immunology, immuno-oncology and cancer biology.
  • Expertise in extending discovery research through translational human biology to clinical development, using biomarker development and validation, and forward and back translation of research and clinical endpoints.
  • Experience leading multi-disciplinary, matrixed teams.
  • Understanding of complex research landscapes globally, ability to identify cutting-edge research and new directions, and connect internal and external colleagues productively.
  • Outstanding management and interpersonal skills.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk
  • Excellent communication, including oral presentation and written skills that can easily be applied to data summaries for regulatory agencies.

Education

  • PhD scientist with 10+ years of pharma/ biotech experience

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Scientist, CRISPR and iPSC Biologist, Platform Biology and Neuroscience

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, this role will work in close collaboration with leaders and scientists to ensure that our platform technology evolves based on a rigorous scientific foundation.  This highly motivated individual with expertise in molecular, cellular and developmental biology will apply state-of-the-art CRISPR CAS9 delivery and editing of cancer cell lines and iPSCs in support of the cancer and neurology discovery portfolio.  This position reports to the VP, Neurology and Platform Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Build capability and conduct CRISPR-CAS9 gene editing to knock-in small tags, introduce mutations, and knock-out genes in cancer cells and iPSCs using RNPs, lentiviral delivery and reporter techniques. Use edited cancer models and iPSC derived neurons to develop targeted protein degradation assays and in vitro disease models to support cancer and neurology programs.
  • Utilize appropriate molecular, genomic, image-based (including FACS) and physiologic methods for characterization of CRISPR gene editing approaches in cancer cells and iPSCs.
  • Partner with biology colleagues to identify and apply appropriate technology solutions to build isogenic control cancer cell lines and iPSCs. This will include building informatics solutions for inventory tracking.
  • Apply differentiation methods to iPSCs to drive neurology discovery programs to assess functional impact of PROTACs and to support mid- to large-scale in vitro cellular pharmacology.
  • Apply expertise in cell biology, cell line development, cell culture and molecular biology to support the broader portfolio our innovative PROTACs therapeutic platform approaches.
  • Maintain accountability for ensuring own goals and those of direct reports are acheived.
  • Demonstrate proficiency with bioinformatic tools to inform design of gRNAs, genomic databases, and computational data analysis tools.
  • Represent the company effectively to external organizations and other company senior management, as needed/requested.
  • Write procedures/protocols and professional/technical reports, including contributions to publications, INDs and patents.

Qualifications

  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding.
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus.
  • Ability to effectively prioritize efforts, manage time, and balance work between bench and desk is critical for success in this role.

Education

  • PhD, or M.S/ B.S. scientist with 8+ years of pharma/ biotech/ academic experience in cellular and molecular biology, neurobiology, pharmacology. Focus on cancer cell biology and neurobiology strongly preferred.

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Investigator/ Scientist, Neurodegeneration (Program Leader)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure progression of PROTACs in neurologic disorders.  This highly motivated individual with expertise in molecular, biochemical, histologic and mechanistic basis of neurodegeneration will apply PROTACs to degrade target proteins in support of the cancer and neurology discovery portfolio.  As a drug hunter, you will be responsible for contributing to critical path lead optimization efforts, development candidate identification and contributions to IND filings.

Principal Responsibilities

  • Build and conduct assays as part of a decisional screening tier aimed at informing PROTAC induced degradation of pathologic protein aggregates in neurodegenerative diseases.
  • Molecular-genetic, circuitry level understanding of neurodegeneration; and examples of incorporating this knowledge into drug discovery.
  • Experience in developing assays to profile compounds using target engagement, mechanistic and functional readouts in neuronal and/ or in vivo models.
  • Experience in the characterization biochemical oligomeric neurodegenerative protein species, effects on neuronal dysfunction and pathologic seeding and extracellular neuronal propagation, is preferred.
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection.
  • Ability to build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Solid understanding of how to leverage CSF, imaging and functional biomarkers to contribute to translational research plans for clinical studies.
  • Excellent communication, including oral presentation and written, skills that can easily be applied to data summaries for regulatory agencies.

Qualifications

  • Ph.D., with 5+ years of post-doctoral experience in cellular and molecular biology, neurobiology, pharmacology or enzymology. Focus on neurobiology and drug discovery preferred with strong publication record.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Senior Research Scientist/Research Investigator, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Qualifications

  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Strong expertise in cancer cell biology, drug discovery approaches and biochemical and biophysical techniques
  • Strength in running and evaluating experiments to measure target engagement, protein degradation, pathway modulation and therapeutic sensitivity in response to compounds
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Excellent communication and interpersonal skills

Education

  • Ph.D, with 3+ years of pharma- or biotech experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology
  • Focus on cancer biology, target validation, and drug discovery strongly preferred
  • Experience in immuno-oncology recommended, but not required

Other Preferred Skills and Knowledge

  • Manages times and balances work between bench and desk
  • Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved
  • Maintains a safe working environment for self and others
  • Represents the company effectively to external organizations and to the Board of Directors and other company senior management, as needed/requested
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Senior Research Associate/Associate Scientist (Biology)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Education and Training

  • BS/MS with 4+ years of Pharma/Biotech drug discovery experience, or PhD with 2+ years of relevant experience

 

Required Skills and Abilities

  • Experience with biochemical and biophysical assay development, to evaluate compound SAR and characterize mode of action
  • Experience with fluorescence-based assay techniques (e.g. TR-FRET, AlphaLISA, FP, etc.) and label-free technologies (e.g. SPR, MST, etc.) is highly desired
  • A solid understanding of protein biochemistry and enzymology
  • Experience with protein expression and purification is preferred
  • High-throughput assay development and screening, plus experience with automated liquid handling instrumentation experience is also preferred
  • Strength in experimental design, execution, and data analysis
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious

 

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com

Associate Scientist / Sr. Associate Scientist (Biology) (4)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

Director/Senior Director, Project Leader, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Reports to: Vice President, Biology

 

Education and Training

  • PhD, with 15+ years of pharma or biotech drug discovery experience, preferably in oncology. Track record of leading research projects to IND-track nomination.

Position Summary

Responsible for the effective management of assigned therapeutic projects in line with company criteria and timelines within a matrix team environment, particularly in collaboration with partner Chemistry project lead

Provide transparent, focused updates to manager and company executives as requested and represent company at scientific conferences, regulatory body meetings and other external organizations as needed

May supervise/mentor junior PhD biologists

 

Requirements

  • Demonstrated success in leading a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong background in cancer biology and signaling with demonstrated expertise in incorporating this knowledge into drug discovery
  • Expertise in developing compound profiling mechanistic and functional assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection, specifically, running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD, safety & efficacy
  • Some bench work may be expected
  • Solid understanding of how to leverage biomarkers and translational research to guide clinical development
  • Contribute to regulatory documents, scientific publications, patents
  • Make scientific contributions that have significant impact on the Arvinas platform and overall research direction of the company
  • Maintain orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Accountability for ensuring own goals, those of any direct reports, project team goals, and project and company objectives are achieved
  • Excellent publication record
  • Maintain a safe working environment for self and others

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Research Scientist/Sr. Research Scientist (Biology) (1)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential

Requirements

  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

 

Chemistry

Computational Chemist

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

An ideal candidate would have a well-trained background in molecular modeling or computational chemistry, having the flexibility to be integrated into the current group as well as work collaboratively with chemists and biologists and having the desire to learn and solve challenging problems. Extensive experience in molecular dynamics simulation, free energy prediction or protein-protein docking is highly sought.  This position reports to the Director of Computational Chemistry and will be located at our headquarters in New Haven, CT.

Primary Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Support and drive the discovery and advancement of PROTACTM targeted protein degraders through computational and molecular modeling input.
  • Work closely with medicinal chemists, biologists and pharmacologists to develop and mature hit identification and lead optimization strategies and to execute from a computational perspective.
  • Develop molecular models and SAR rules in both classical and non-classical scenarios.
  • Perform virtual screening and compound design using structure-based design methods.
  • Participate in selecting, evaluating and implementing software suites.
  • Maintain enterprise cheminformatics database and electronic notebook systems.
  • Demonstrate deep expertise in theoretical and hands-on structure-based and ligand-based drug design.
  • Perform work on multiple classes of drug targets.
  • Apply strong understanding of modeling and computational principles related to protein conformation, protein-ligand interaction and physicochemical properties of compounds.

Qualifications

  • > 4 years of drug discovery experience, industrial experience preferred.
  • Work experience in at least two areas from: virtual screening, docking, de novo design, compound redesign or optimization, molecular dynamics simulation, free energy perturbation, QSAR, DMPK models.
  • Advanced knowledge of Schrödinger’s drug discovery suite.
  • Experience in managing Linux workstations and cloud instances is a plus. Experience in cheminformatics is a plus.
  • Development and coding experience is a plus.
  • Strong track-record of patents and publications.
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas.
  • Demonstrate excellent communication skills, including oral presentation and writing capabilities.

Education

  • Ph.D. in a computational chemistry/molecular modeling-related area.

 

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

CMC


 

G & A

Senior Intellectual Property Counsel

Arvinas is a pharmaceutical company focused on developing new small molecule PROTAC® targeted protein degraders aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Arvinas is at exciting stage in its growth as a company.  The company has initiated its first Phase 1 study for ARV-110 for patients with prostate cancer and expects its next drug candidate, ARV-471 for patients with breast cancer, to enter the clinic during 2019.  Also in 2019, Arvinas expects to present new data on its neurodegeneration program (tau).  Arvinas is growing rapidly, having roughly doubled in size in 2018 while also completing its initial public offering (IPO; NASDAQ:ARVN).  For more information, visit www.arvinas.com.

Position Summary

Arvinas is seeking a Senior Intellectual Property Counsel with experience in the biotechnology and life science industry to serve as a key member of our legal team. You will report to the VP of Businss Development and Legal and advise on intellectual property legal practice including IP strategy, patent prosecution, FTO, trade secret protection, trademark filing, diligence, as well as transactional matters. You will partner with business groups across the company, including research, clinical, and business development functions and have broad involvement in work central to Arvinas’ strategic goals. You will apply your existing technical skills, learn new skills, and play a key role in helping grow the company and guide its direction.

As Senior Intellectual Property Counsel at Arvinas, you will represent and address IP issues with Arvinas’ leadership. You will have the opportunity to develop a broad intellectual property strategy and guide the business. You should be intellectually curious and ready to enthusiastically take on novel intellectual property and industry issues. You will be expected to analyze information and have the ability to effectively advise senior management and team members.  This role has the opportunity to be part of setting the vision and patent strategy for the company that will drive development, use and commercialization of products in the field of targeted protein degradation.

Principal Responsibilities

  • Define, design and implement Arvinas’ IP strategy with respect to internal R&D pipeline, partners, competitors, and suppliers
  • Develop and manage a multilayered strategic patent portfolio, including drafting and prosecuting patent applications worldwide, to create an intellectual property portfolio aligned with the strategy of Arvinas.
  • Collaborate across departments to provide practical intellectual property advice in alignment with business strategies and objectives.
  • Analyze and advise business on navigating identified IP risks.
  • Stay abreast of a rapidly evolving technology, IP, and market landscape with respect to internal technical developments, competitive position, and FTO.
  • Manage all aspects of global patent portfolio procurement, including pre- and post-grant proceedings, reissues, reexaminations and opposition practices, and adverse proceedings as they may arise.
  • Independently provide global strategic direction to US outside counsel and foreign agents on patent filing and prosecution matters.
  • Support intellectual property litigation (offense and defense), partnering with outside counsel, other in-house counsel and clients to efficiently achieve successful outcomes.
  • Educate clients on important intellectual property issues and forge strong client relationships that leverage opportunities to identify, create and protect valuable intellectual property.
  • Identify patentable inventions through frequent interactions with internal and external R&D project teams, facilitate the creation of appropriate patent protection strategies and execute on those strategies with guidance as needed.
  • Collaborate and provide IP support for agreements (including MTAs, CDAs, research collaborations, and licensing agreements).
  • Supervise Arvinas’ current patent attorney.

Education & Qualifications

  • JD with 10+ years of experience in drafting and prosecuting patent applications, developing strategic patent portfolios, conducting patentability and freedom to operate analyses in biotechnology and/or pharmaceuticals either in-house, private practice, or both.
  • Experience in active small molecule patent prosecution preferred.
  • D. in chemistry, biomedical engineering or microbiology, or another discipline relevant to biopharmaceutical drug research and development is highly desired.
  • Admission to practice before the U.S. Patent and Trademark Office (USPTO).
  • Experience counseling clients in biopharmaceutical research and development programs.
  • Highly collaborative with strong professionalism and interpersonal skills.
  • Must have excellent written and verbal communications skills.
  • Experience with transactional work and licensing a plus.
  • Public company experience preferred.

Competencies

  • Ability to develop pragmatic, business-centric approaches for managing intellectual property risks.
  • Exceptional critical thinking and problem-solving skills.
  • Ability to identify, analyze and render legal advice on complex intellectual property issues.
  • A global business enterprise view, with recognition of the potential commercial implications of an intellectual property issue within a region or country.
  • Clear potential to establish professional credibility with clients by delivering clear, concise and accurate advice, including the appropriate level of detail and anticipation of follow-up questions.
  • Ability to balance legal and business considerations, prioritize activities, and execute efficiently
  • Demonstrated ability to multi-task, problem solve, and operate in a fast-paced environment
  • Influence business leaders as a trusted advisor and thought partner.
  • Excellent professionalism and interpersonal skills with sound judgment and commitment to ethical conduct.
  • Strong verbal and written communication skills, including proven ability to interact and communicate effectively with individuals from multiple departments at all levels of the organization.
  • Ability to interface with outside counsel, vendors, collaborators, internal functions and all levels of management.

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer  

 

Staff Accountant

Arvinas is a public pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

Rapid growth and recent IPO has fueled the need for an experienced Staff Accountant to join our accounting and finance team. The Staff Accountant will be a key player in the the monthly close process, preparation of internal and external (SEC) reporting and general accounting functions.

This position reports to the Accounting Manager and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Reconcile balance sheet accounts and prepare journal entries as needed
  • Analyze financial results for internal and external reporting
  • Assist in the preparation of SEC reports (e.g. – 10-K, 10-Q)
  • Research and document accounting issues
  • Maintain fixed asset system
  • Assist in the documentation and testing of internal controls (SOX)
  • Support accounts payable activities
  • Assist with the payroll system and payroll related items
  • Preparation of supporting documenttion for income tax provision and return
  • Prepare other tax filings
  • Perform such other accounting, financial or administrative tasks as may be required

Qualifications

  • Proficient in Word and Excel
  • SOX and SEC reporting experience a plus
  • Pharma/biotech experience a plus
  • Great Plains Dynamics experience a plus

Education

  • Bachelor’s Degree or higher in accounting required
  • 5+ years’ experience

Competencies

  • Excellent written and oral communication skills
  • Detail oriented
  • Ability to multi-task, establish priorities and efficiently organize

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Director, Corporate and Commercial Development

 

Arvinas is a biopharmaceutical company creating new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ that degrade disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer, neurological disorders, and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Arvinas is at exciting stage in its growth as a company.  The company expects its first two drug candidates, ARV-110 and ARV-471, to enter the clinic in 2019 for patients with prostate cancer and breast cancer, respectively.  Also in 2019, Arvinas expects to present compelling new data on its neurodegeneration program (tau).  Arvinas is growing rapidly, having roughly doubled in size in 2018 while also completing its initial public offering (IPO; NASDAQ:ARVN).  For more information, visit www.arvinas.com.

Position Summary

At Arvinas, Corporate Development includes responsibilities in Corporate Strategy, Commercial Development, Business Development, Investor Relations, and Communications.  The Associate Director, Corporate and Commercial Development will report to, work closely with, and be a key strategic partner to the Vice President, Corporate Development.  The ideal candidate will be excited to roll up their sleeves across multiple disciplines in a fast-paced, entreprenurial environment.

Given the breadth of responsiblities, there is flexibility with regards to both candidate experience and to how the various responsiblities below are prioritized.

Principal Responsibilities

This will be a high-profile role where the candidate will gain firsthand strategic and operating experience while helping to build a premier biopharmaceutical company. The high energy individual will “wear many hats” and have the capacity to drive numerous complex projects forward simultaneously. This position will require both strategic and operational excellence while working closely with senior management and business partners.

Corporate Strategy

  • Develop and maintain strategic frameworks to make decisions regarding the prioritization of new targets, therapeutic areas, and disease states
  • Provide input and support to new target prioritization
  • Understand disease biology, mechanism of potential intervention, current treatment paradigms and competitive landscape to inform decisions regarding potential clinical programs
  • Support the strategic planning process, as well as strategic input to annual budget planning
  • Build and own long-term corporate financial models for Arvinas, including scenario analyses
  • With stakeholders across the company, reinforce and communicate Arvinas’ mission
  • Ensure Arvinas’ corporate strategy is reflected consistently across internal materials, investor presentations, and external communications
  • Support the development of presentations to the senior team and/or board of directors
  • Identify critical risks to Arvinas’ strategy and prioritize potential mitigations
  • Work directly with the executive team to prioritize and lead strategic initiatives

Commercial Development

  • Lead commercial analyses/assessments for portfolio prioritization and decisions across therapeutic areas and indications
  • Develop and communicate strong understanding of treatment protocols, unmet needs, potential patient segments, and competitive pipeline in order to identify targeted product concepts and necessary product profiles
  • Create and maintain target product profiles (TPP) for potential and pipeline assets
  • Provide strategic commercial input to pipeline programs in early and mid-stage development
  • Develop business cases for prioritized targets
  • Conduct diligence on competitors/precedents to inform business cases
  • Provide commercial input to clinical trial design, regulatory approaches, and other aspects of development
  • Provide commercial forecasting and analytical support for pipeline programs in the long-range plan
  • Provide commercial input to business development opportunities
  • Develop and maintain competitive intelligence views for pipeline programs

Business Development

  • Conduct competitive and business/financial analysis to support the transaction process, including benchmarking of analogous BD deals
  • Contribute to BD strategy by analyzing scientific and industry trends and competitive environment
  • Create and maintain valuation models of potential transactions, executing scenario analyses, and evaluating alternative deal constructs
  • Support the development of BD materials and presentations

Education & Qualifications

  • BA/BS degree required; advanced degree preferred
  • 4+ years total relevant work experience (pharmaceuticals or biotech) required
  • Within biopharmaceuticals, experience in business development or commercial development (or new product planning) preferred
  • Outside biopharmaceuticals, experience in management consulting, banking, private equity, or venture capital preferred
  • Oncology experience is a plus
  • Previous hybrid experience in financial and scientific/commercial analysis strongly preferred

Competencies

  • High self-motivation and aptitude for working in a dynamic, collaborative, fast paced, and deadline-driven environment
  • Ability to build relationships at all levels and across diverse areas of the company, including Research and Development, Legal, CMC, and Finance
  • Adept at facilitating productive discussion and debate by listening effectively and managing stakeholders
  • Passion for helping patients through innovative science
  • Independent, persistent problem solving and the ability to work successfully with ambiguity
  • Strong analytical and problem-solving skills; ability to combine attention to detail with big picture perspective
  • Desire and ability to manage multiple complex projects simultaneously
  • Good knowledge of drug discovery, development, and commercialization processes
  • Excellent written, verbal, computer and social media knowledge and skills
  • Excellent communication, organizational, and planning skills
  • Strong Microsoft Office (Excel, Outlook, Word, PowerPoint) skills
  • Public biotech company experience preferred
  • Knowledge in oncology/immuno-oncology therapeutic area preferred

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   


 

IT