Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Vice President of CMC


Senior executive responsible for all CMC activities from preclinical to product launch. Oversight of drug substance (API) and drug product (DP) production for preclinical safety/clinical testing and commercialization. Responsible for development, scale-up, analytical testing of API and DP. Oversight of identification, hiring and management of external vendors and CMO’s. Responsible for representing Arvinas CMC function in meetings with regulatory authorities and submission of CMC documentation consistent with relevant regulations and guidelines.

Particular expertise in pre-formulation and formulation development required. Must be familiar with oral, subcutaneous and IV dosage forms with experience in handling poorly soluble and poorly permeable molecules. This position reports to the Chief Development Officer.


  • Development of the Pharmaceutical R&D function, technical capabilities, and work flows;
  • Responsible for budgeting and financial planning of CMC efforts;
  • Management of formulation, analytical methods and process development functions through oversight of internal personnel and external partners;
  • Serve as CMC subject matter expert to Project Teams;
  • Manage and provide technical guidance to CROs and CMOs in API and DP development and production efforts;
  • Manage establishment product specifications applying stage-appropriate and risk-based approach;
  • Provide guidance on quality control strategies and operations from early development through registration;
  • Build and maintain strong working relationships with relevant internal Development and Discovery functions to effectively support on-going programs;
  • CMC reviewer and SME for formulation and drug product regulatory submissions and agency interactions


  • D. in chemistry, materials science, or related physical science. A combination of relevant education and applicable job experience may be considered.
  • Minimum 10 years of Formulation and Pharmaceutical Development experience in the biotech/pharmaceutical industry.
  • Strong leadership and management abilities.
  • A critical and strategic thinker with exceptional decision making abilities.
  • Excellent communication, problem-solving and organizational skills; thrives in a cross-functional team environment.
  • Experience and demonstrated success in formulation development and delivery across a range of molecules, and through all stages of development.
  • Extensive working knowledge of GxP practices, ICH guidelines, and other regulatory practices.
  • Extensive knowledge of the scientific literature and of emerging research areas of pharmaceutical science.
  • Familiar with analytical methods and instrumentation used to characterize APIs, dosage forms, and drug products.
  • Understanding of chemical and physical properties of APIs and excipients as they relate to formulation, process and drug delivery
  • Experience and understanding of Design of Experiments (DOE), Quality by Design (QbD), Process Analytical Technology (PAT), scale up, formulation and process technologies


  • Experience with small molecule formulation R&D across multiple platforms including IV, subcutaneous and oral.

Please send CV and cover letter to:

Patent Agent


Provide assistance with intellectual property matters, with particular emphasis in preparing and prosecuting applications, and patent portfolio management; Conduct scientific and technical evaluations, publication searching and review; Answer general US patent law and procedure related questions from inventors; Assess whether inventions are new and innovative and therefore eligible to be patented; Review Office Actions and references for rejections from The United States Patent and Trademark Office (USPTO); Read invention disclosures and draft patent applications; Communicate and work with outside counsel and USPTO examiners about patent applications; Discuss with inventors about inventions.


At least a Master’s degree in Chemical Engineering, Medicinal Chemistry, Organic Chemistry or a related field and 2 years related experience. Foreign degree equivalent is acceptable. Experience to include drafting patent applications, responding to office actions and providing advice on prosecution strategies. Must have passed patent bar examination.


Please send CV and cover letter to:

Research Scientist/Sr. Research Scientist (Biology)

Arvinas, a new start-up company based in New Haven, CT, is seeking innovative, collaborative and experienced biologists with expertise in cancer biology to investigate oncology biology as well as to develop novel, targeted therapeutics that address critical therapeutic targets to benefit patients suffering from cancer. Knowledge of the underpinnings of cancer therapeutic approaches is preferred but not essential. These positions require facility in working across disciplines to integrate the efforts of a project team to drive the discovery of novel small molecule therapeutics & deliver them for clinical testing.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential


  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Please send CV and cover letter to:

Associate Scientist / Sr. Associate Scientist (Biology)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Please send CV and cover letter to: