Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Director, Formulation Research and Development


REPORTS TO:                                 VP Chemistry, Manufacturing, and Controls

The Director will serve as a core member of the development team and lead the overall formulation strategy for Arvinas drug candidates. The Director will be responsible for executing all research and development studies, as well as clinical supply manufacture through in-house efforts and CDMOs. The Director of Formulation Development will provide strategic and technical leadership in the development and manufacturing of all new oral, SC, and IV formulations to support clinical studies and ultimately robust commercial products. He/She will work closely with process chemistry, clinical supply logistics, and clinical to develop and execute a streamlined program to advance an asset into clinic and then into commercialization.  The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

Responsibilities include research on and development of formulations to support enabling exploratory and pre-clinical animal studies, as well as clinical studies.  This will be accomplished through a blend of in-house and out-sourced activities.  In addition to a hands-on component, the incumbent will be responsible for preparing requests-for-proposals, negotiating contracts, and directing and monitoring the activities of several formulation development and manufacturing organizations.  The incumbent will provide critical analysis of on-going development activities and continually assess the suitability of a particular formulation for its intended use. A key activity of this role will be the assembly/evaluation of pharmaceutical study data and drafting of the relevant sections of INDs and NDAs.  In addition, the incumbent will be expected provide technical insights and support for new product development to meet corporate goals and objectives.



  • Conducts in-house preformulation studies and the associated analytical profiling.
  • Develops fit-for-purpose formulations to enable exploratory and enabling animal studies
  • Provides strategic leadership, technical expertise, and specialized knowledge in formulation development and drug product manufacturing to support the Arvinas portfolio of drug candidates.
  • Prepares requests-for-proposals, negotiates contracts, and directs and monitors the activities of several formulation development and manufacturing organizations.
  • Applies scientifically-driven thinking to the development of formulations and products which meet pre-determined product profiles.
  • Evaluates data associated with characterization of drug products and stability testing and assess suitability of a drug product for an intended purpose and commercialization potential.
  • Converts data on formulations/products into knowledge required for IND and NDA filings. Drafts the relevant sections of these regulatory filings.
  • Works closely with peers on project teams to seamlessly and expeditiously advance Arvinas assets into the clinic and on to the commercial market.


  • Ph.D. in chemistry, pharmaceutical chemistry, or other relevant scientific discipline
  • 15 years or more in the pharmaceutical industry with a minimum of 10 years in formulation research and development and manufacturing of New Medical Entities
  • Demonstrated success in formulation of BCS Class IV compounds
  • Experience with creating RFPs, negotiating contracts and managing CDMOs for pre-formulation, formulation development, and manufacturing of drug product
  • Both hands-on experience with formulation development/manufacturing and technical leadership of groups engaged in same.
  • Comprehensive working knowledge of Good Manufacturing Practices (cGMPs) and Regulatory Guidance Documents as they relate to manufacture and quality testing of pharmaceutical products
  • Ability to establish and maintain effective working relationships
  • Ability to effectively prioritize and deliver on tight timelines
  • Outstanding problem solving abilities
  • Detail-oriented, with good organizational and project management skills
  • Good oral and written communications skills
  • Proficient with MS Word, PowerPoint, Excel
  • Strong leadership, project planning, negotiation and presentation skills as well as an ability to contribute innovative solutions to problems
  • Experience with management of all stages of formulation development from inception to commercial manufacturing
  • Significant experience in communicating/presenting complex information to senior management and regulatory agencies.
  • Ability to multi-task and manage several projects in parallel, paying attention to detail
  • Ability to forge cross-functional working relationships with internal and external project partners
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation and/or progression of the trial and resolve the issues in a timely and creative fashion

Job Requirements – Personality

  • Conduct themselves in an ethical, honest and accountable manner
  • Ability to work in a fast-paced, highly-motivated work environment
  • Entrepreneurial with self-starting personality; ability to prioritize and manage multiple responsibilities simultaneously
  • Enthusiastic desire to roll up sleeves and dig in. Confidence in own abilities to get things done.
  • Able to meet tight deadlines on multiple priorities.
  • Strong analytical skills with attention to detail and accuracy
  • Customer focused with strong team work, interpersonal and communication skills
  • Requirement to maintain a high level of confidentiality
  • Ability to develop solutions to problems and implement them.

Associate Chemist

As an associate chemist at Arvinas you will interact with a cross disciplinary research team aimed at the discovery and development of novel small molecule Proteolysis Targeting Chimeras (PROTACs) targeted towards multiple areas of unmet medical need. Your responsibilities will include planning, designing and executing multi-step synthetic sequences towards key molecules followed by purification, gathering of analytical data, and documenting your work in an electronic notebook. Participation in team meetings, internal presentations, contributing to documentation for external publications / presentations, and creative contributions to all areas of our PROTAC platform are essential.

Job Requirements and Responsibilities include:

  • BS or MS in Organic or Medicinal Chemistry with 5+ years experience in a laboratory setting
  • Extensive hands on experience with modern synthetic organic chemistry, and purification techniques including automated silica gel chromatography, preparative HPLC and crystallization techniques
  • A working knowledge of modern analytical techniques including NMR, MS, LC/MS and IR
  • The ability to troubleshoot and optimize organic reactions in a timely and independent manner
  • Familiarity with SciFinder and other literature searching engines
  • Making contributions to publications derived from project data
  • The ability to operate and maintain scientific laboratory equipment
  • Maintaining external awareness of scientific discipline through familiarity with current scientific literature
  • Attending technical staff and departmental meetings
  • Observance of appropriate safety and study requirements by reading, understanding and following Standard Operating Procedures (SOP) and study protocols
  • Knowledge of Microsoft Office Suites Products and chemical drawing programs including Chemdraw and Marvinsketch
  • A proven ability to work in a collaborative team environment

Research Scientist/Sr. Research Scientist (Biology)

Arvinas, a new start-up company based in New Haven, CT, is seeking innovative, collaborative and experienced biologists with expertise in cancer biology to investigate oncology biology as well as to develop novel, targeted therapeutics that address critical therapeutic targets to benefit patients suffering from cancer. Knowledge of the underpinnings of cancer therapeutic approaches is preferred but not essential. These positions require facility in working across disciplines to integrate the efforts of a project team to drive the discovery of novel small molecule therapeutics & deliver them for clinical testing.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential


  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Please send CV and cover letter to:

Associate Scientist / Sr. Associate Scientist (Biology)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Please send CV and cover letter to: