Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Biology

Director/ Senior Director, Translational Science

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

We are seeking an experienced scientist who will be responsible for the translational aspects of our current clinical compounds as well as our upcoming clinical stage drug candidates. You will ultimately lead a group of PhD and non-PhD level scientists, and guide the group in developing translational strategies for each program, such as disease indication selection, PD and patient selection biomarker identification, dose/scheduling strategy, combination strategy, and drug candidate differentiation, etc. The ideal candidate will have successful experience in filing multiple INDs and extensive expertise in preclinical and clinical translational biomarker development. Outstanding track record of scientific achievement is required. Prior experience in managing a group of PhD level scientists with excellent soft skills is necessary.

This position reports to the Chief Scientific Officer and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Build and lead a group of PhD and non-PhD level scientists to conduct preclinical and translational drug development from candidate nomination to phase I, by developing action plans, strategy and go/no go criteria at each stage of this process.
  • Oversee generation, management, analysis and interpretation of biomarker and pharmacodynamic data coming from the clinical trials of our two lead Oncology assets.
  • Generate additional preclinical data to support the Clinical Development Plan for our clinical assets
  • Build and lead a group of PhD and non-PhD level scientists to conduct preclinical and translational drug development from candidate nomination to phase I, by developing action plans, strategy and go/no go criteria at each stage of this process.
  • Guide the group in developing translational strategies for each program, such as disease indication selection, PD and patient selection biomarker identification, dose/scheduling strategy, combination strategy, and drug candidate differentiation, etc.
  • Generate understanding of biomarker prevalence and biomarker interplay with prognostic biomarkers and biomarkers for SOC, across lines of therapy in solid tumor and hematologic cancer indications of interest.
  • Lead the effort of exploring new biomarker assay platforms to enable high quality analysis of preclinical and clinical biomarkers.
  • Guide MOA studies to gain a deep understanding of drug properties in order to guide clinical development strategy.
  • Serve as the point person for the early discovery teams to implement translational thinking to early stages of drug discovery, such as target selection and lead optimization; Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.

 

Qualifications

  • Experience in IND enabling studies and multiple IND filings with small molecule oncology drugs
  • Experience in preclinical and clinical translational biomarker development
  • Basic understanding of toxicology, DMPK and clinical pharmacology
  • Knowledge in oncology clinical trial design is preferred, experience in CDx development is a plus

Education

  • Ph.D. in biochemistry, cell or molecular biology, pharmacology, medical science, or related fields
  • At least eight years of drug development experience and minimal 5 years of management expertise in industry

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Director/ Senior Director, Neurobiology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Education and Training

  • Ph.D, with 10+ years of industry/ biotech leadership experience in neurobiology and pharmacology with clear contributions to clinical candidates.

Requirements

  • Track record of innovation in the discovery of translational biomarkers of therapeutics for Tauopathies, Parkinson’s Disease and other neurodegenerative diseases.
  • Established scientific reputation and statistical rigor in the study of neurodegeneration as evidenced by strong publication record, relationships with key opinion leaders and effective leader of external science and collaborations.
  • Demonstrated ability to lead, recruit, mentor, develop and motivate a team of creative, experienced scientists.
  • Strong team leader who guides cross functional scientists to build deep mechanistic and pharmacologic relationships including target engagement and function in human and rodent neuronal systems, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples.
  • Communicates effectively with employees, colleagues, leadership teams and the broader external neuroscience community as evidenced by publications, presentations, inventions and contributions to clinical candidates for regulatory filings.
  • Contributions to biomarker plans and pharmacodynamic biomarker assay development. Deep track record of contributions to IND documentation.
  • Confident self-starter with a strong work ethic

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer  

Director/Senior Director, Immunology/Immuno-oncology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will develop and integrate a research strategy, and build a team, to apply the PROTAC technology in the areas of immunology/immuno-oncology.  This highly motivated individual must have a solid working knowledge of innate and adaptive immune cell biology and tumor/immune cell interactions.  You will ensure the progression of projects from concept to clinical testing, focusing on developing PROTACs with a strong translational rationale. This scientific leader will maintain a connection to the appropriate research communities, establishing and managing productive collaborations with external scientists to help drive innovation.  This position reports to the Chief Scientific Officer and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

  • Identify and validate targets using a variety of tools, including human immunology, human genetics, human sample analyses, bioinformatics, clinical data, and preclinical in vitro and in vivo models
  • Develop assays to profile compounds using target engagement, mechanistic and functional readouts in the appropriate in vitro and in vivo model systems to support structure-activity relationships that guide lead identification, optimization and development candidate selection
  • Implement new models and technologies to incorporate into drug discovery and advance portfolio projects
  • Build and work on cross-disciplinary, drug discovery project teams; integrating and evaluating the work of multiple drug discovery functions.
  • Build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Incorporate knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Recruit, retain, and develop world-class scientific talent.
  • Lead and participate on cross-disciplinary, drug discovery project teams; integrate and evaluate the work of multiple drug discovery groups / functions to determine optimal solutions to discovery challenges.
  • Educate, support, coach, mentor, motivate, and grow scientists who are developing expertise in immuno-oncology, in either a supervisory or matrix leadership capacity.

Qualifications

  • Deep expertise and outstanding record of research and publications in immunology, immuno-oncology and cancer biology.
  • Expertise in extending discovery research through translational human biology to clinical development, using biomarker development and validation, and forward and back translation of research and clinical endpoints.
  • Experience leading multi-disciplinary, matrixed teams.
  • Understanding of complex research landscapes globally, ability to identify cutting-edge research and new directions, and connect internal and external colleagues productively.
  • Outstanding management and interpersonal skills.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk
  • Excellent communication, including oral presentation and written skills that can easily be applied to data summaries for regulatory agencies.

Education

  • PhD scientist with 10+ years of pharma/ biotech experience

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Investigator/ Scientist, Neurodegeneration (Program Leader)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure progression of PROTACs in neurologic disorders.  This highly motivated individual with expertise in molecular, biochemical, histologic and mechanistic basis of neurodegeneration will apply PROTACs to degrade target proteins in support of the cancer and neurology discovery portfolio.  As a drug hunter, you will be responsible for contributing to critical path lead optimization efforts, development candidate identification and contributions to IND filings.

Principal Responsibilities

  • Build and conduct assays as part of a decisional screening tier aimed at informing PROTAC induced degradation of pathologic protein aggregates in neurodegenerative diseases.
  • Molecular-genetic, circuitry level understanding of neurodegeneration; and examples of incorporating this knowledge into drug discovery.
  • Experience in developing assays to profile compounds using target engagement, mechanistic and functional readouts in neuronal and/ or in vivo models.
  • Experience in the characterization biochemical oligomeric neurodegenerative protein species, effects on neuronal dysfunction and pathologic seeding and extracellular neuronal propagation, is preferred.
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection.
  • Ability to build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Solid understanding of how to leverage CSF, imaging and functional biomarkers to contribute to translational research plans for clinical studies.
  • Excellent communication, including oral presentation and written, skills that can easily be applied to data summaries for regulatory agencies.

Qualifications

  • Ph.D., with 5+ years of post-doctoral experience in cellular and molecular biology, neurobiology, pharmacology or enzymology. Focus on neurobiology and drug discovery preferred with strong publication record.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Scientist/ Sr. Associate Scientist, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Execute protein expression and purification
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

 

Qualifications

  • General knowledge of cancer biology
  • In vitro and or ex vivo tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Proficiency in flow cytometry and data analysis a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS/MS in Biology or relevant discipline, or equivalent education and experience with >3 years Pharma/Biotech experience

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Chemistry

MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Clinical Development

Senior Director, Clinical Pharmacology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

Arvinas is searching for an agile and innovative Clinical Pharmacology leader to provide both day-to-day operational support and design pharmacology strategy on our high-priority development programs.  This critical role will collaborate closely with colleagues across the R&D organization and may select and direct internal and external teams of clinical pharmacology experts.  This role will work across diverse therapeutic areas and will be accountable for the delivery of clinical pharmacology and modeling and simulation strategy, delivery of PK and drug metabolism data from Phase I through Phase II/III of development, optimization of dosing regimens, and authoring relevant clinical and regulatory reports, documents, and publications.

This position reports to the Chief Medical Officer and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and implementation of Clinical Pharmacology plans for oncology and neuroscience drug development programs.
  • Provide Clinical Pharmacology representation on Drug Development Teams, providing clinical pharmacology input to the overarching clinical development plan.
  • Direct human clinical pharmacology trials, Phases I–IV, for programs under development.
  • Write clinical pharmacology portions of development protocols, clinical study reports, regulatory submission documents; contribute as required to relevant publications, and respond to regulatory questions related to clinical pharmacology.
  • Collaborate with preclinical scientists and pharmacologists, analyze translational models developed from preclinical data to predict human PK and develop efficacious dose projections.
  • Evaluate and perform hands-on analysis of clinical PK, safety and efficacy data and present clinical pharmacology results to internal and external stakeholders.
  • Utilize PK modeling to support dosing strategies for clinical programs.
  • Ensure quality of documentation for internal and external studies in compliance with global regulatory submission requirements

Qualifications

  • Expertise in PK/ PD, DM, DDI trials, and experience in developing clinical pharmacology plans for small molecules required.
  • Demonstrable expertise in interpreting and providing guidance on modeling and simulation activities applicable to PK and PD
  • Must have flexibility to work seamlessly across multiple development programs and provide pharmacology expertise across a diverse portfolio including multiple therapeutic areas.
  • Expertise in building and leading teams, including selection and management of key internal and external partners.  Experience overseeing external CROs in driving delivery of critical data very strongly preferred.
  • Excellent oral and written communication skills required.
  • Strong knowledge of drug development process; deep understanding of technical, business, and regulatory issues.
  • Demonstrated success in team leadership, with at least 3 years of management experience is preferred.

Education

  • MD, PharmD, or PhD with at least 10 years of bio/pharmaceutical industry drug development experience in clinical pharmacology.

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Senior Medical Director, Clinical Development

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

The Oncology Senior Medical Director will be a critical link with investigators and key opinion leaders in the external oncology community. He/She will work closely with these experts, developing the clinical trial strategy, designing clinical trials, and identifying appropriate investigators for the studies. This individual will serve as a key strategic and medical point person during the conduct of the trials, monitoring safety of ongoing trials and leading efforts to analyze and present data from clinical studies. The selected individual will work closely with other physicians, scientists, regulatory professionals, statisticians and members of the clinical operations department to carry out these responsibilities. The individual will respond to inquiries by practitioners and investigators, IRBs, regulatory bodies, and vendors. This person will work to establish relationships with key opinion leaders, external advisors and collaborators.  This position reports to our Chief Medical Officer and is located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Collaborate with physicians, scientists, regulatory professionals, biostatisticians, regulatory, executive staff and others as necessary for development of clinical development strategy and clinical protocols, and analysis of data from these trials and trials with other molecules.
  • In collaboration with ARVINAS clinical operations staff, consultants and CROs, support clinical trial execution to achieve timely completion of clinical stud
  • Assume medical responsibility for clinical tria Actively participate in real-time medical monitoring of studies, including assessment of patient eligibility and responses to study design questions.
  • Provide safety monitoring in collaboration with CRO pharmacovigilance group of active clinical studie
  • Collaborate with associates (and/or consultants) in Regulatory, CMC, Toxicology, Research, Pharmacology to progress clinical compounds from preclinical through Phase 1 – 3 clinical development, in a project team
  • Participate in clinical study report writing and review, using his/her medical expertise to identify ways to best analyze and present data in a complete, accurate and scientifically sound
  • Collaborate with Principal Investigators in the evaluation and assessment of publications (abstracts, posters, manuscripts) associated with clinical dat
  • Other responsibilities that may apply, as periodically assigned by his/her supervisor.

 

Qualifications

  • 5+ years of clinical development experience in solid tumor oncology.
  • Strong technical/analytical skills to identify and solve problems.
  • Self-motivated and confident with the ability to act with urgency and passion.
  • Proven ability to work with a high level of integrity, accuracy, and attention to detail.
  • Strong organizational skills in order to maintain a high level of productivity, innovation, and priority-setting in order to complete assignments on-time and on-budget.
  • Excellent oral and written communication skills for effectively interfacing with all levels of management and departments within the company.
  • Ability to make thoughtful, integrated, timely and meaningful decisions and take corresponding actions.
  • Willingness to work collaboratively by incorporating diverse perspectives and appropriately managing relationships in order to strength decision-making.
  • Proactively seeks out and recommends process improvements.
  • Resourceful, creative, enthusiastic, and results-oriented.
  • Entrepreneurial, enjoys working in a fast-paced, small-company environment.
  • Experience with managing or participating in breast oncology clinical
  • Successful academic research publication history or history of medical practice in a relevant
  • Experience presenting medical data and concepts to a variety of audiences (medical, scientific, vendors) in a credible and engaging manner.
  • Solid understanding of the clinical landscape relevant to oncology patients and health care practitioners in the
  • Daily user of Office tools (Word, Excel, PowerPoint, etc).
  • Demonstrated application of critical thinking skills to problem solving, data analysis, and strategic planning.
  • High degree of emotional Can work successfully in a demanding environment while constantly maintaining a professional demeanor.

 

Education

  • Doctor of Medicine degree (MD) or equivalent, MD/PhD pre

 

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

CMC

Research Scientist/ Senior Research Scientist, Formulation R&D

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

The Research Scientist will serve as a core member of the development team and execute formulation strategy for Arvinas drug candidates. The incumbent will be responsible for executing exploratory research and development studies, as well as supporting preclinical supply manufacture through in-house experimental efforts and CDMOs. In addition, the successful candidate will support the in vivo group in preparing dosing solutions and designing vehicles for BCS II/IV compounds.  He/She will work closely with in vivo, biology, chemistry, and when necessary, clinical groups to develop vehicles and formulation to advance assets into preclinical and early clinical studies.  The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

This position reports to the Executive Director, Formulation Research & Development, and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Responsibilities include research on and development of formulations to support enabling exploratory and pre-clinical animal studies, as well as clinical studies.  Most of this will be accomplished through direct laboratory work with the opportunity to leverage out-sourced activities.  In addition to a hands-on component, the incumbent will be responsible for preparing requests-for-proposals and monitoring the activities of several formulation development and manufacturing organizations.  The incumbent will provide critical analysis of on-going development activities and continually assess the suitability of a particular formulation for its intended use. A key activity of this role will be the assembly/evaluation of pharmaceutical study data and assisting in its incorporation of the relevant sections of regulatory documents, e.g. INDs and NDAs.

Key responsibilities of this role include, but are not limited to:

  • Design, carry out, and interpret preformulation studies on new and potential drug candidates, with the purpose of defining their physicochemical and biopharmaceutical properties relevant to oral and parenteral administration.
  • Develop fit-for-purpose formulations to enable exploratory and enabling animal studies.
  • Provide technical expertise, and specialized knowledge in formulation development and drug product manufacturing to support the Arvinas portfolio of drug candidates.
  • Work closely with in-life groups to develop and prepare formulations suitable for use in drug discovery pharmacology, pharmacokinetic, and toxicology studies.
  • Assist in the preparation of requests-for-proposals, selection of vendors, and monitoring the activities/emergent data of/from formulation development and manufacturing organizations.
  • Apply scientifically-driven thinking to the development of formulations and products which meet pre-determined product profiles.
  • Analyze and evaluate data associated with characterization of drug products and stability testing and assess suitability of a drug product for an intended purpose.
  • Convert data on formulations/products into knowledge required for regulatory filings, e.g. IND and NDA. Assist in drafting the relevant sections of these documents.
  • Works closely with peers on project teams to seamlessly and expeditiously advance Arvinas assets into the clinic.
  • Assist in the development of clinical parenteral formulations.
  • Maintain a state-of-the-art understanding of formulation/drug-delivery technologies and how they are best applied to identification and enablement of beyond rule-of-five compounds.

 

 

Qualifications

  • Hands-on, laboratory experience with formulation development/manufacturing of BCS II/IV compounds.
  • An understanding of basic medicinal chemistry and biopharmaceutical principles as they apply to drug discovery and development.
  • A willingness to take on challenging problem statements and acquire/apply the skills necessary to address them.
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation and/or progression of a study and resolve the issues in a timely and creative fashion.
  • Ability to effectively prioritize and deliver on tight timelines.
  • Appreciate the necessity of thinking innovatively and reduce such thinking to practical implementation enabling the discovery and development of new molecular entities.
  • Experience in communicating/presenting complex information to scientists from other disciplines.
  • Ability to multi-task and manage several projects in parallel, paying attention to detail.
  • Ability to forge cross-functional working relationships with internal and external project partners.
  • Good oral and written communications skills.
  • Experience in using computers and databases for data collection, compilation, analysis, and information dissemination.
  • Proficient with MS Word, PowerPoint, Excel, and HPLC systems.

Education

  • PhD, with 4-10 years of experience in industrial drug development, or MS in Pharmaceutical / Medicinal / Physical / Analytical Chemistry, with 10-12 years of experience in industrial drug development required.

Competencies

  • Incumbent must conduct themselves in an ethical, honest, and accountable manner.
  • Ability to establish and maintain effective working relationships.
  • Ability to work in a fast-paced, highly motivated work environment.
  • Entrepreneurial with self-starting personality; ability to prioritize and manage multiple responsibilities simultaneously.
  • Enthusiastic desire to roll up sleeves and dig in.  Confidence in own abilities to get things done.
  • Able to meet tight deadlines on multiple priorities.
  • Strong analytical skills with attention to detail and accuracy.
  • Customer focused with strong teamwork, interpersonal and communication skills.
  • Requirement to maintain a high level of confidentiality.
  • Ability to develop solutions to problems and implement them.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   


G & A

Specialist, Facilities Technician

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As Arvinas continues to expand, we have a need for a Facilities Technician to support our exciting growth plan!  This key role will perform light building, and equipment, maintenance, liaise with employees and vendors, prepare for on- and off-site events, support environmental, health, safety, shipping, receiving, and waste management efforts, among other varied tasks.  The Facilities Technician will work to ensure that Arvinas facility operations run safely and smoothly while being efficient and cost-effective.

This is an hourly, overtime-eligible position.  Typical working schedule will be Monday-Friday, however, occasional weekend/ after-hours work may be required as driven by business need.  This position reports to the CFO and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Conducts and/or assists in troubleshooting, repairs (corrective maintenance) and preventative maintenance of process equipment, building support systems, utility systems, automation systems, and laboratory systems
  • Perform shipping and receiving duties for laboratory supplies and compounds
  • Works with Lab representatives to maintain a working supply of disposables in the labs
  • Interprets electrical schematics, I/O wiring and panel drawings, utility, process system/equipment, plumbing, ductwork, and HVAC P&ID’s—liaise with external vendors in support of these systems.
  • Constructively, collaboratively, and professionally interact with peers, company leadership, vendors, and visitors.
  • Performs general labor, construction, and minor repair duties as needed and may be required to work in awkward locations
  • Manage and execute office/ laboratory moves, respond to employee requests, assist in space-planning efforts, and maintain accurate records
  • Support preparation/ set-up and take-down for on-site and off-site activities
  • Works to limit any interruptions, disruptions, or losses arising from unscheduled downtime of client services. Systems operations and maintenance must be safe, reliable, and cost-effective.
  • Attends all mandatory safety training and maintains a safe work environment by following OSHA/ IACUC/ etc. guidelines, relevant GxP regulations, and all facility safety policies and procedures.
  • May assist in designing and drafting facility-related SOPs. Takes prompt action to correct conditions found to be out of compliance or unsafe.
  • Escalate risks and concerns throughout the organization appropriately.

Qualifications

  • Five (5) years of facility maintenance experience is required.
  • Pharmaceutical/ Biotech/ Laboratory/ Vivarium-related experience preferred; knowledge of GxP standards is a plus.
  • Strong organizational and interpersonal skills required, to facilitate interactions with diverse group of internal and external stakeholders (including employees, senior leadership, external vendors, etc.)
  • Excellent oral and written communication skills are required.
  • Strong proficiency in trouble-shooting and problem-solving is required.
  • Must be willing to work overtime to include starting work early or staying late past scheduled work hours based on business needs, if required.
  • Must be willing to work some weekends/ company holidays based on a relevant business need, if required.
  • Must be able to lift 40 lbs
  • Must be able to work using respirator

Education

  • High school diploma from an accredited school.
  • Vocational/trade school training is a plus.

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   


IT

Senior Engineer, IT Infrastructure and Operations

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

Arvinas is seeking a Senior Engineer to administer and provide operations services for its technical infrastructure.  This role works closely with the Vice President, Information Technology and the IT leadership team to provide expertise, implementation execution, and support for IT solutions that enhance mission-critical business operations. This position focuses on the data center and cloud services, hardware and operation, LAN/WAN networking, plus systems and data security both within and connecting to our infrastructure.  In addition, this role contributes to client end point management best practices and delivery of those supportive services and policies.  Collaborating with the Vice President, Information Technology and strategic IT partners, the Senior Engineer executes the IT service portfolios for each business unit/department and the service level agreements for the user community within the organization.

 

This position reports to the VP, Information Technology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Execute timely and consistent administration and operations responsibilities,
  • Deliver high-quality core infrastructure, and
  • Provide input to the IT team to develop network, server infrastructure, and operations systems.
  • Provide technical expertise in resolving both user system and infrastructure deficiencies.  Monitor and resolve support tickets for client end points and network, server, and storage infrastructure.
  • Create, monitor, and modify (as necessary) automated operations jobs to ensure success, completion, and adherence to stakeholder requirements, including backup jobs, system scans, and security and configuration change alerts.
  • Ensure infrastructure is up-to-date on all security and system patches and updates, including server operating systems, virus definitions, IT administrative applications, and infrastructure firmware.
  • Monitor system performance and security through creation of reports and dashboards.  Regularly review these with the Vice President, Information Technology.
  • Perform routine maintenance and configuration work as needed by the business (i.e., managing configurations on switches, setting up new client end point or laboratory instrument connections at drops and in wiring closets, troubleshooting connectivity issues, upgrading or installing new features in server operating systems, managing backup and replication jobs, creating new volumes or shares and installing hardware drives in storage infrastructure, etc.).
  • Ensure optimum network configuration and architecture for Arvinas’ evolving connectivity needs.  Work with IT partners to develop and execute best practices.
  • Perform analysis of system performance issues, makes modification of systems to increase operational efficiency, and reinstates system integrity as quickly as possible following an outage in order to minimize item and data loss.
  • Identify client end point management best practices, implements needed systems, scripts, and/or security policies, and manages end points throughout hardware and software lifecycle.
  • Recommend and authorizes system upgrades and software installations.
  • Research and recommends new system tools.
  • Maintain client end point and systems inventories, network topology diagrams, and service catalogs for systems and infrastructure.
  • Assist the Director, R&D systems with infrastructure setups for laboratory environments, including isolating research systems on VLANs, identifying opportunities and restrictions around antivirus and backup operations for instrument and analysis computers and executing identified plans, etc.
  • Collaborate with IT team and partners to identify opportunities to enhance, improve, and use new networking, server, or storage infrastructure.
  • Analyze execution time and success of operations activities to identify and remediate inefficient or ineffective tasks and scripts.
  • Analyze, evaluate, and act to circumvent problems and restore systems to operating condition.
  • Create system specifications and determines the combination of options needed to tailor operating systems and infrastructure configurations to meet the business needs.
  • Research new technologies, processes, and methodologies.
  • Provide accurate and on-time updates to team members, project managers, and management team.

 

Qualifications

  • 5+ years of related experience.
  • Advanced knowledge in computer systems and technologies, basic project management principles, and applicable laws and regulations as they relate to IT and the pharmaceutical industry.
  • Experience with the following software/ applications/ tasks is required:
    • VMWare vSphere and vCenter
    • Amazon Web Services and Azure/Azure AD
    • Microsoft technologies, including Active Directory, DNS, DHCP, certificate authorities, and fluency in PowerShell
    • Routing protocols and network monitoring protocols
    • Net gear, Cisco, and Dell network technologies
  • Experience with the following software/ applications/ tasks is preferred:
    • Vulnerability scanning, penetration testing, and disaster recovery
    • Linux administration skills
  • Excellent communication skills (oral and written), excellent interpersonal skills, excellent analytical and problem-solving skills, demonstrated ability to apply IT in solving business problems, strong negotiation skills, keen attention to detail, self-motivated and directed with a service orientation.
  • Ability to communicate complex network principles and server/storage concepts to non-technical and technical staff.
  • Ability to work independently.

 

Education

  • Four-year college degree (or equivalent knowledge gained through formal education, specialized training, or additional job experience).

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer