Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Biology

Research Scientist/ Investigator, Neurodegeneration

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure progression of PROTACs in neurologic disorders.  This highly motivated individual with expertise in molecular, biochemical, histologic and mechanistic basis of neurodegeneration will apply PROTACs to degrade target proteins in support of the cancer and neurology discovery portfolio.  As a drug hunter, you will be responsible for contributing to critical path lead optimization efforts, development candidate identification and contributions to IND filings.

Principal Responsibilities

  • Build and conduct assays as part of a decisional screening tier aimed at informing PROTAC induced degradation of pathologic protein aggregates in neurodegenerative diseases.
  • Molecular-genetic, circuitry level understanding of neurodegeneration; and examples of incorporating this knowledge into drug discovery.
  • Experience in developing assays to profile compounds using target engagement, mechanistic and functional readouts in neuronal and/ or in vivo models.
  • Experience in the characterization biochemical oligomeric neurodegenerative protein species, effects on neuronal dysfunction and pathologic seeding and extracellular neuronal propagation, is preferred.
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection.
  • Ability to build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Solid understanding of how to leverage CSF, imaging and functional biomarkers to contribute to translational research plans for clinical studies.
  • Excellent communication, including oral presentation and written, skills that can easily be applied to data summaries for regulatory agencies.

 

Qualifications

  • D., with 5+ years of post-doctoral experience in cellular and molecular biology, neurobiology, pharmacology or enzymology. Focus on neurobiology and drug discovery preferred with strong publication record.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Director/ Senior Director, Translational Science

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

We are seeking an experienced scientist who will be responsible for the translational aspects of our current clinical compounds as well as our upcoming clinical stage drug candidates. You will ultimately lead a group of PhD and non-PhD level scientists, and guide the group in developing translational strategies for each program, such as disease indication selection, PD and patient selection biomarker identification, dose/scheduling strategy, combination strategy, and drug candidate differentiation, etc. The ideal candidate will have successful experience in filing multiple INDs and extensive expertise in preclinical and clinical translational biomarker development. Outstanding track record of scientific achievement is required. Prior experience in managing a group of PhD level scientists with excellent soft skills is necessary.

This position reports to the Chief Scientific Officer and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Build and lead a group of PhD and non-PhD level scientists to conduct preclinical and translational drug development from candidate nomination to phase I, by developing action plans, strategy and go/no go criteria at each stage of this process.
  • Oversee generation, management, analysis and interpretation of biomarker and pharmacodynamic data coming from the clinical trials of our two lead Oncology assets.
  • Generate additional preclinical data to support the Clinical Development Plan for our clinical assets
  • Build and lead a group of PhD and non-PhD level scientists to conduct preclinical and translational drug development from candidate nomination to phase I, by developing action plans, strategy and go/no go criteria at each stage of this process.
  • Guide the group in developing translational strategies for each program, such as disease indication selection, PD and patient selection biomarker identification, dose/scheduling strategy, combination strategy, and drug candidate differentiation, etc.
  • Generate understanding of biomarker prevalence and biomarker interplay with prognostic biomarkers and biomarkers for SOC, across lines of therapy in solid tumor and hematologic cancer indications of interest.
  • Lead the effort of exploring new biomarker assay platforms to enable high quality analysis of preclinical and clinical biomarkers.
  • Guide MOA studies to gain a deep understanding of drug properties in order to guide clinical development strategy.
  • Serve as the point person for the early discovery teams to implement translational thinking to early stages of drug discovery, such as target selection and lead optimization; Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.

 

Qualifications

  • Experience in IND enabling studies and multiple IND filings with small molecule oncology drugs
  • Experience in preclinical and clinical translational biomarker development
  • Basic understanding of toxicology, DMPK and clinical pharmacology
  • Knowledge in oncology clinical trial design is preferred, experience in CDx development is a plus

Education

  • Ph.D. in biochemistry, cell or molecular biology, pharmacology, medical science, or related fields
  • At least eight years of drug development experience and minimal 5 years of management expertise in industry

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Scientist/ Sr. Associate Scientist, Biology (Strategic Collaborations)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Execute protein expression and purification
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

 

Qualifications

  • General knowledge of cancer biology
  • In vitro and or ex vivo tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Proficiency in flow cytometry and data analysis a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS with 8+ years experience or MS in Biology or relevant discipline with 3+ years experience

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Scientist/ Senior Research Scientist, Biology (Strategic Collaborations)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This key position is for a drug discovery and development project leader to support external partnership/ collaboration efforts across one or more diverse therapeutic areas.  The incumbent may supervise a small team of Research Associates.

This position reports to our Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Develop compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Assay optimization to ensure quality and easily interpretable data is generated
  • Present data and project plans in project team meetings
  • Build strong alliances with external partners, focused on trust, collaboration, and timely/ high-quality delivery on shared objectives.

Qualifications

  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • A demonstrated ability to innovate and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy
  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • Broad scientific skillset with expertise in assay development, cell signaling, cell biology, and protein analysis
  • Demonstrable skill at building productive relationships with internal and external stakeholders at all levels, ability to influence and seek innovative solutions to complex scientific and strategic challenges.
  • Recruit, retain, and develop world-class scientific talent
  • Lead and participate on cross-disciplinary, drug discovery project teams; integrate and evaluate the work of a drug discovery group to determine optimal solutions to discovery challenges
  • Educate, support, coach, mentor, motivate, and grow scientists who are developing expertise in various therapeutic areas, in either a supervisory or matrix leadership capacity

Education

  • Ph.D, with 3+ years of productive post-doctoral fellowship experience or equivalent in biomedical research, cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential.
  • Strong publication record desired.

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

(Senior) Director, Neurobiology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Education and Training

  • Ph.D, with 10+ years of industry/ biotech leadership experience in neurobiology and pharmacology with clear contributions to clinical candidates.

Requirements

  • Track record of innovation in the discovery of translational biomarkers of therapeutics for Tauopathies, Parkinson’s Disease and other neurodegenerative diseases.
  • Established scientific reputation and statistical rigor in the study of neurodegeneration as evidenced by strong publication record, relationships with key opinion leaders and effective leader of external science and collaborations.
  • Demonstrated ability to lead, recruit, mentor, develop and motivate a team of creative, experienced scientists.
  • Strong team leader who guides cross functional scientists to build deep mechanistic and pharmacologic relationships including target engagement and function in human and rodent neuronal systems, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples.
  • Communicates effectively with employees, colleagues, leadership teams and the broader external neuroscience community as evidenced by publications, presentations, inventions and contributions to clinical candidates for regulatory filings.
  • Contributions to biomarker plans and pharmacodynamic biomarker assay development. Deep track record of contributions to IND documentation.
  • Confident self-starter with a strong work ethic

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer  

Director/Senior Director, Immunology/Immuno-oncology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will develop and integrate a research strategy, and build a team, to apply the PROTAC technology in the areas of immunology/immuno-oncology.  This highly motivated individual must have a solid working knowledge of innate and adaptive immune cell biology and tumor/immune cell interactions.  You will ensure the progression of projects from concept to clinical testing, focusing on developing PROTACs with a strong translational rationale. This scientific leader will maintain a connection to the appropriate research communities, establishing and managing productive collaborations with external scientists to help drive innovation.  This position reports to the Chief Scientific Officer and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

  • Identify and validate targets using a variety of tools, including human immunology, human genetics, human sample analyses, bioinformatics, clinical data, and preclinical in vitro and in vivo models
  • Develop assays to profile compounds using target engagement, mechanistic and functional readouts in the appropriate in vitro and in vivo model systems to support structure-activity relationships that guide lead identification, optimization and development candidate selection
  • Implement new models and technologies to incorporate into drug discovery and advance portfolio projects
  • Build and work on cross-disciplinary, drug discovery project teams; integrating and evaluating the work of multiple drug discovery functions.
  • Build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Incorporate knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Recruit, retain, and develop world-class scientific talent.
  • Lead and participate on cross-disciplinary, drug discovery project teams; integrate and evaluate the work of multiple drug discovery groups / functions to determine optimal solutions to discovery challenges.
  • Educate, support, coach, mentor, motivate, and grow scientists who are developing expertise in immuno-oncology, in either a supervisory or matrix leadership capacity.

Qualifications

  • Deep expertise and outstanding record of research and publications in immunology, immuno-oncology and cancer biology.
  • Expertise in extending discovery research through translational human biology to clinical development, using biomarker development and validation, and forward and back translation of research and clinical endpoints.
  • Experience leading multi-disciplinary, matrixed teams.
  • Understanding of complex research landscapes globally, ability to identify cutting-edge research and new directions, and connect internal and external colleagues productively.
  • Outstanding management and interpersonal skills.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk
  • Excellent communication, including oral presentation and written skills that can easily be applied to data summaries for regulatory agencies.

Education

  • PhD scientist with 10+ years of pharma/ biotech experience

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Investigator/ Scientist, Neurodegeneration (Program Leader)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure progression of PROTACs in neurologic disorders.  This highly motivated individual with expertise in molecular, biochemical, histologic and mechanistic basis of neurodegeneration will apply PROTACs to degrade target proteins in support of the cancer and neurology discovery portfolio.  As a drug hunter, you will be responsible for contributing to critical path lead optimization efforts, development candidate identification and contributions to IND filings.

Principal Responsibilities

  • Build and conduct assays as part of a decisional screening tier aimed at informing PROTAC induced degradation of pathologic protein aggregates in neurodegenerative diseases.
  • Molecular-genetic, circuitry level understanding of neurodegeneration; and examples of incorporating this knowledge into drug discovery.
  • Experience in developing assays to profile compounds using target engagement, mechanistic and functional readouts in neuronal and/ or in vivo models.
  • Experience in the characterization biochemical oligomeric neurodegenerative protein species, effects on neuronal dysfunction and pathologic seeding and extracellular neuronal propagation, is preferred.
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions.
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection.
  • Ability to build exposure and pharmacodynamic relationships in preclinical models to drive a human dose projection. Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy.
  • Solid understanding of how to leverage CSF, imaging and functional biomarkers to contribute to translational research plans for clinical studies.
  • Excellent communication, including oral presentation and written, skills that can easily be applied to data summaries for regulatory agencies.

Qualifications

  • Ph.D., with 5+ years of post-doctoral experience in cellular and molecular biology, neurobiology, pharmacology or enzymology. Focus on neurobiology and drug discovery preferred with strong publication record.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, a plus
  • Manages time and balances work between bench and desk

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Scientist/ Sr. Associate Scientist, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Execute protein expression and purification
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

 

Qualifications

  • General knowledge of cancer biology
  • In vitro and or ex vivo tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Proficiency in flow cytometry and data analysis a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS/MS in Biology or relevant discipline, or equivalent education and experience with >3 years Pharma/Biotech experience

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Chemistry

DNA Encoded Library (DEL) Selection Biologist

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As one of the key hires for the company, this individual will work in close collaboration with leaders and scientists to ensure progression of PROTACs against oncology and neurology disorders.  This highly motivated individual with expertise in biochemistry and molecular biology will be the point person for DNA Encoded Library (DEL) screening.  This position reports to the Sr. Director of Platform Chemistry and will be located at our headquarters in New Haven, CT.

Primary Responsibilities

  • Support and drive the discovery and advancement of targeted protein degraders (PROTAC® molecules) through DNA Encoded Library (DEL) screening for target and E3 ligase ligands.
    • Target validation
    • Selection design & format optimization
    • Protein Immobilization
    • Selection of DEL hits
    • PCR amplication of DEL tags and prep. for NGS
    • Coordinate and oversee NGS
    • Assist in data analysis
    • Hit confirmation with DNA tag removed
  • Support and drive the discovery and advancement of targeted protein degraders (PROTAC® molecules) through display methods (phage, yeast, mRNA, etc)
    • Design expression vectors for phage, yeast, bacterial, or mRNA display
      • Familiarity with various affinity tags and purification methods (affinity selection, SEC, IEX, etc.) is a plus.
    • Generate plasmid preps and characterize by restriction enzyme digests and sequencing
    • Analyze sequencing data – Sanger and NGS
    • Independently design and execute the production of complex plasmids by cloning, using either PCR or gene synthesis, to a high technical standard
    • Design and execute relevant display panning methods to identify and screen hits
    • Perform Cloning of Phage display hits into mammalian expression vectors

 

  • Serve as point person for all equipment and projects related to DEL selection and peptide display
    • Purchase and set up laboratory equipment for DEL section and display protein purification.

 

Qualifications

 

  • Strong protein biochemistry skills and experience with protein purification and immobilization using various affinity tags (His, avi, etc)
  • Hands on experience in DEL selection is a strong plus
  • Experience and successful demonstration of hit identification with one or more display methods (phage, yeast, mRNA, etc)
  • Strong experience and skills in molecular biology applications; PCR, restriction enzyme, and sequencing methods
  • A successful candidate will have an entreupenurial attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas.
  • High degree of independence.
  • Strong communication skills.
  • Maintainance of accurate records

Education

 

  • PhD, or M.S/ B.S. scientist with 8+ years of pharma/ biotech/ academic experience in molecular biology, biochemistry, biophysics, chemistry or a related field.

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

CMC

Research Scientist/ Senior Research Scientist, Formulation R&D

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

The Research Scientist will serve as a core member of the development team and execute formulation strategy for Arvinas drug candidates. The incumbent will be responsible for executing exploratory research and development studies, as well as supporting preclinical supply manufacture through in-house experimental efforts and CDMOs. In addition, the successful candidate will support the in vivo group in preparing dosing solutions and designing vehicles for BCS II/IV compounds.  He/She will work closely with in vivo, biology, chemistry, and when necessary, clinical groups to develop vehicles and formulation to advance assets into preclinical and early clinical studies.  The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

This position reports to the Executive Director, Formulation Research & Development, and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Responsibilities include research on and development of formulations to support enabling exploratory and pre-clinical animal studies, as well as clinical studies.  Most of this will be accomplished through direct laboratory work with the opportunity to leverage out-sourced activities.  In addition to a hands-on component, the incumbent will be responsible for preparing requests-for-proposals and monitoring the activities of several formulation development and manufacturing organizations.  The incumbent will provide critical analysis of on-going development activities and continually assess the suitability of a particular formulation for its intended use. A key activity of this role will be the assembly/evaluation of pharmaceutical study data and assisting in its incorporation of the relevant sections of regulatory documents, e.g. INDs and NDAs.

Key responsibilities of this role include, but are not limited to:

  • Design, carry out, and interpret preformulation studies on new and potential drug candidates, with the purpose of defining their physicochemical and biopharmaceutical properties relevant to oral and parenteral administration.
  • Develop fit-for-purpose formulations to enable exploratory and enabling animal studies.
  • Provide technical expertise, and specialized knowledge in formulation development and drug product manufacturing to support the Arvinas portfolio of drug candidates.
  • Work closely with in-life groups to develop and prepare formulations suitable for use in drug discovery pharmacology, pharmacokinetic, and toxicology studies.
  • Assist in the preparation of requests-for-proposals, selection of vendors, and monitoring the activities/emergent data of/from formulation development and manufacturing organizations.
  • Apply scientifically-driven thinking to the development of formulations and products which meet pre-determined product profiles.
  • Analyze and evaluate data associated with characterization of drug products and stability testing and assess suitability of a drug product for an intended purpose.
  • Convert data on formulations/products into knowledge required for regulatory filings, e.g. IND and NDA. Assist in drafting the relevant sections of these documents.
  • Works closely with peers on project teams to seamlessly and expeditiously advance Arvinas assets into the clinic.
  • Assist in the development of clinical parenteral formulations.
  • Maintain a state-of-the-art understanding of formulation/drug-delivery technologies and how they are best applied to identification and enablement of beyond rule-of-five compounds.

 

 

Qualifications

  • Hands-on, laboratory experience with formulation development/manufacturing of BCS II/IV compounds.
  • An understanding of basic medicinal chemistry and biopharmaceutical principles as they apply to drug discovery and development.
  • A willingness to take on challenging problem statements and acquire/apply the skills necessary to address them.
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation and/or progression of a study and resolve the issues in a timely and creative fashion.
  • Ability to effectively prioritize and deliver on tight timelines.
  • Appreciate the necessity of thinking innovatively and reduce such thinking to practical implementation enabling the discovery and development of new molecular entities.
  • Experience in communicating/presenting complex information to scientists from other disciplines.
  • Ability to multi-task and manage several projects in parallel, paying attention to detail.
  • Ability to forge cross-functional working relationships with internal and external project partners.
  • Good oral and written communications skills.
  • Experience in using computers and databases for data collection, compilation, analysis, and information dissemination.
  • Proficient with MS Word, PowerPoint, Excel, and HPLC systems.

Education

  • PhD, with 4-10 years of experience in industrial drug development, or MS in Pharmaceutical / Medicinal / Physical / Analytical Chemistry, with 10-12 years of experience in industrial drug development required.

Competencies

  • Incumbent must conduct themselves in an ethical, honest, and accountable manner.
  • Ability to establish and maintain effective working relationships.
  • Ability to work in a fast-paced, highly motivated work environment.
  • Entrepreneurial with self-starting personality; ability to prioritize and manage multiple responsibilities simultaneously.
  • Enthusiastic desire to roll up sleeves and dig in.  Confidence in own abilities to get things done.
  • Able to meet tight deadlines on multiple priorities.
  • Strong analytical skills with attention to detail and accuracy.
  • Customer focused with strong teamwork, interpersonal and communication skills.
  • Requirement to maintain a high level of confidentiality.
  • Ability to develop solutions to problems and implement them.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   


 

G & A

Specialist, Facilities Technician

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

As Arvinas continues to expand, we have a need for a Facilities Technician to support our exciting growth plan!  This key role will perform light building, and equipment, maintenance, liaise with employees and vendors, prepare for on- and off-site events, support environmental, health, safety, shipping, receiving, and waste management efforts, among other varied tasks.  The Facilities Technician will work to ensure that Arvinas facility operations run safely and smoothly while being efficient and cost-effective.

This is an hourly, overtime-eligible position.  Typical working schedule will be Monday-Friday, however, occasional weekend/ after-hours work may be required as driven by business need.  This position reports to the CFO and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Conducts and/or assists in troubleshooting, repairs (corrective maintenance) and preventative maintenance of process equipment, building support systems, utility systems, automation systems, and laboratory systems
  • Perform shipping and receiving duties for laboratory supplies and compounds
  • Works with Lab representatives to maintain a working supply of disposables in the labs
  • Interprets electrical schematics, I/O wiring and panel drawings, utility, process system/equipment, plumbing, ductwork, and HVAC P&ID’s—liaise with external vendors in support of these systems.
  • Constructively, collaboratively, and professionally interact with peers, company leadership, vendors, and visitors.
  • Performs general labor, construction, and minor repair duties as needed and may be required to work in awkward locations
  • Manage and execute office/ laboratory moves, respond to employee requests, assist in space-planning efforts, and maintain accurate records
  • Support preparation/ set-up and take-down for on-site and off-site activities
  • Works to limit any interruptions, disruptions, or losses arising from unscheduled downtime of client services. Systems operations and maintenance must be safe, reliable, and cost-effective.
  • Attends all mandatory safety training and maintains a safe work environment by following OSHA/ IACUC/ etc. guidelines, relevant GxP regulations, and all facility safety policies and procedures.
  • May assist in designing and drafting facility-related SOPs. Takes prompt action to correct conditions found to be out of compliance or unsafe.
  • Escalate risks and concerns throughout the organization appropriately.

Qualifications

  • Five (5) years of facility maintenance experience is required.
  • Pharmaceutical/ Biotech/ Laboratory/ Vivarium-related experience preferred; knowledge of GxP standards is a plus.
  • Strong organizational and interpersonal skills required, to facilitate interactions with diverse group of internal and external stakeholders (including employees, senior leadership, external vendors, etc.)
  • Excellent oral and written communication skills are required.
  • Strong proficiency in trouble-shooting and problem-solving is required.
  • Must be willing to work overtime to include starting work early or staying late past scheduled work hours based on business needs, if required.
  • Must be willing to work some weekends/ company holidays based on a relevant business need, if required.
  • Must be able to lift 40 lbs
  • Must be able to work using respirator

Education

  • High school diploma from an accredited school.
  • Vocational/trade school training is a plus.

Please send CV and cover letter to: careers@arvinas.com.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Manager, Financial Planning &Analysis (FP&A)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Arvinas is at exciting stage in its growth as a company.  The company has initiated its first Phase 1 study for ARV-110 for patients with prostate cancer and expects its next drug candidate, ARV-471 for patients with breast cancer, to enter the clinic during 2019.  Also in 2019, Arvinas expects to present compelling new data on its neurodegeneration program (tau).  Arvinas is growing rapidly, having roughly doubled in size in 2018 while also completing its initial public offering (IPO; NASDAQ:ARVN).  For more information, visit www.arvinas.com.

 

Position Summary

We are looking for a Financial Planning and Analysis Manager to join our growing Finance organization. You will be responsible for the financial planning and analysis of critical areas of the business and you will serve as a business partner to members of the executive and leadership teams.

The Manager, FP&A will play an integral role in the financial planning, reporting and analysis process for Arvinas.  You will assist in the preparation of financial plans and forecasts based on the strategies determined by the senior management team.  Additionally, you will gather and publish various financial reports and analysis including historical, current and forward looking financial plans.

This position will report to the CFO at our headquarters in New Haven, CT.

Principal Responsibilities

  • Lead and manage the development of annual operating budgets and ongoing forecasts
  • Drive variance analysis against budgets for departments, identify risks and opportunities
  • Develop and maintain key reporting metrics
  • Monthly reporting and analysis of company results from both a financial and operational perspective for the executive team and business partners
  • Assist in preparation of monthly management reporting package for executive and leadership teams
  • Assist in preparation of presentations for Board of Directors and other Corporate meetings
  • Support preparation of the monthly financial reporting package, including actual vs. budget variance analysis
  • Assist the Finance team in the quarterly financial forecast process to update the organization on projected financial performance
  • Provide capex, opex, and headcount reporting and analytics
  • Participate in monthly and quarterly business review processes
  • Engage functional business leaders to provide timely and relevant financial information and analyses to enable sound decision making
  • Develop relationships with leaders across the organization
  • Maintain and provide relevant updates to various reporting and planning models
  • Work collaboratively with Accounting to ensure alignment with budget
  • Other ad hoc projects as necessary.

 

Education & Qualifications

  • BA/BS degree in Finance, Business or related field of study. MBA, CPA or CMA a plus
  • 7+ years of relevant experience
  • Biopharmaceutical experience preferred
  • Must have strong analytical, mathematical, and advanced excel modeling skills
  • Professional written and verbal communication and interpersonal skills
  • Ability to participate in and facilitate group meetings and work with cross functional leaders
  • Ability to prioritize and meet deadlines in a fast-paced environment
  • Highly collaborative with strong business partnership and influencing skills
  • Responsible and extremely resourceful in finding answers and solutions when information and data is not readily available
  • Ability to communicate effectively with all levels of management

Competencies

  • Demonstrated ability to multi-task, problem-solve and operate in a fast paced environment
  • Strong verbal and written communication skills, including proven ability to interact and communicate effectively with individuals from multiple departments at all levels of the organization
  • Excellent professionalism and interpersonal skills with sound judgment and commitment to ethical conduct
  • Ability to handle confidential and proprietary information using excellent discretion and judgment
  • Exceptional critical thinking and problem-solving skills
  • Strong organizational and time management skills in order to balance working on multiple projects
  • Outstanding attention to detail

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Senior Intellectual Property Counsel

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Arvinas is at exciting stage in its growth as a company.  The company has initiated its first Phase 1 study for ARV-110 for patients with prostate cancer and expects its next drug candidate, ARV-471 for patients with breast cancer, to enter the clinic during 2019.  Also in 2019, Arvinas expects to present new data on its neurodegeneration program (tau).  Arvinas is growing rapidly, having roughly doubled in size in 2018 while also completing its initial public offering (IPO; NASDAQ:ARVN).  For more information, visit www.arvinas.com.

Position Summary

Arvinas is seeking a Senior Intellectual Property Counsel with experience in the biotechnology and life science industry to serve as a key member of our legal team. You will report to the VP of Businss Development and Legal and advise on intellectual property legal practice including IP strategy, patent prosecution, FTO, trade secret protection, trademark filing, diligence, as well as transactional matters. You will partner with business groups across the company, including research, clinical, and business development functions and have broad involvement in work central to Arvinas’ strategic goals. You will apply your existing technical skills, learn new skills, and play a key role in helping grow the company and guide its direction.

As Senior Intellectual Property Counsel at Arvinas, you will represent and address IP issues with Arvinas’ leadership. You will have the opportunity to develop a broad intellectual property strategy and guide the business. You should be intellectually curious and ready to enthusiastically take on novel intellectual property and industry issues. You will be expected to analyze information and have the ability to effectively advise senior management and team members.  This role has the opportunity to be part of setting the vision and patent strategy for the company that will drive development, use and commercialization of products in the field of targeted protein degradation.

Principal Responsibilities

  • Define, design and implement Arvinas’ IP strategy with respect to internal R&D pipeline, partners, competitors, and suppliers
  • Develop and manage a multilayered strategic patent portfolio, including drafting and prosecuting patent applications worldwide, to create an intellectual property portfolio aligned with the strategy of Arvinas.
  • Collaborate across departments to provide practical intellectual property advice in alignment with business strategies and objectives.
  • Analyze and advise business on navigating identified IP risks.
  • Stay abreast of a rapidly evolving technology, IP, and market landscape with respect to internal technical developments, competitive position, and FTO.
  • Manage all aspects of global patent portfolio procurement, including pre- and post-grant proceedings, reissues, reexaminations and opposition practices, and adverse proceedings as they may arise.
  • Independently provide global strategic direction to US outside counsel and foreign agents on patent filing and prosecution matters.
  • Support intellectual property litigation (offense and defense), partnering with outside counsel, other in-house counsel and clients to efficiently achieve successful outcomes.
  • Educate clients on important intellectual property issues and forge strong client relationships that leverage opportunities to identify, create and protect valuable intellectual property.
  • Identify patentable inventions through frequent interactions with internal and external R&D project teams, facilitate the creation of appropriate patent protection strategies and execute on those strategies with guidance as needed.
  • Collaborate and provide IP support for agreements (including MTAs, CDAs, research collaborations, and licensing agreements).
  • Supervise Arvinas’ current patent attorney.

Education & Qualifications

  • JD with 10+ years of experience in drafting and prosecuting patent applications, developing strategic patent portfolios, conducting patentability and freedom to operate analyses in biotechnology and/or pharmaceuticals either in-house, private practice, or both.
  • Experience in active small molecule patent prosecution preferred.
  • Ph.D. in chemistry, biomedical engineering or microbiology, or another discipline relevant to biopharmaceutical drug research and development is highly desired.
  • Admission to practice before the U.S. Patent and Trademark Office (USPTO).
  • Experience counseling clients in biopharmaceutical research and development programs.
  • Highly collaborative with strong professionalism and interpersonal skills.
  • Must have excellent written and verbal communications skills.
  • Experience with transactional work and licensing a plus.
  • Public company experience preferred.

Competencies

  • Ability to develop pragmatic, business-centric approaches for managing intellectual property risks.
  • Exceptional critical thinking and problem-solving skills.
  • Ability to identify, analyze and render legal advice on complex intellectual property issues.
  • A global business enterprise view, with recognition of the potential commercial implications of an intellectual property issue within a region or country.
  • Clear potential to establish professional credibility with clients by delivering clear, concise and accurate advice, including the appropriate level of detail and anticipation of follow-up questions.
  • Ability to balance legal and business considerations, prioritize activities, and execute efficiently
  • Demonstrated ability to multi-task, problem solve, and operate in a fast-paced environment
  • Influence business leaders as a trusted advisor and thought partner.
  • Excellent professionalism and interpersonal skills with sound judgment and commitment to ethical conduct.
  • Strong verbal and written communication skills, including proven ability to interact and communicate effectively with individuals from multiple departments at all levels of the organization.
  • Ability to interface with outside counsel, vendors, collaborators, internal functions and all levels of management.

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer  

 


 

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