Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Biology

Associate Scientist/ Sr. Associate Scientist, Biology (Immuno-Oncology)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC®-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This is an exciting position in the Immuno-Oncology group at Arvinas. This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Working knowledge of flow cytometry is highly desired
  • Experience in working with human immune cells is a plus but not required.
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

 

Qualifications

  • General knowledge of cancer biology and/or immunology
  • In vitro and or ex vivo tissue culture techniques
  • Familiarity with mouse models of tumor development and/or inflammatory diseases is highly desired but not required.
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS/MS in Biology or relevant discipline, or equivalent education and experience with >3 years Pharma/Biotech experience

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Scientist/ Sr. Associate Scientist, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Execute protein expression and purification
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

 

Qualifications

  • General knowledge of cancer biology
  • In vitro and or ex vivo tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Proficiency in flow cytometry and data analysis a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS/MS in Biology or relevant discipline, or equivalent education and experience with >3 years Pharma/Biotech experience

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Research Associate / Assistant Platform Biology (Biophysics)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

We are looking for a scientist to strengthen our biophysics team. This position will directly use primarily biophysical and biochemical methods to characterize the binding of ligands for transformation into PROTACs. This position will provide the key, critical data necessary to drive programs toward targeted degradation.

This position reports to the Senior Associate Scientist in our Platform Biology group and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Utilization of assay design techniques, quality control and execution of medium- to high- throughput 96/384 well assay formats, such as SPR, MST, AlphaLISA, quantitative Bioluminescent/ Fluorescence assays, and other biophysical/biochemical approaches
  • Incumbent will also learn how to apply biophysical techniques to PROTAC discovery through determination of binding affinities, binding kinetics and protein-protein interactions
  • Leverage and think about principles behind multiple assay platforms for measuring target engagement, biophysical approaches including SPR, MST, TR-FRET, AlphaLISA, and apply them to the ubiquitin-proteasome system and targeted protein degradation
  • Apply excellent organizational and prioritization skills; demonstrate accomplished biologic and biochemical academic record with laboratory experience.  Analyze data using strong background in quantitative sciences.
  • Openness to mastering additional target engagement techniques.
  • Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs.  Troubleshoot through technical and scientific challenges in order to deliver critical data.
  • Organize experimental results to be shared with project teams; openly communicate with chemistry; maintain clear experimental records.

 

Qualifications

  • A strong work ethic and willingness to learn drug discovery approaches in biochemical and cellular target engagement is a requirement. Strong theoretical knowledge in biophysics and biochemistry is a plus.
  • Prior hands-on experience in analyzing protein-protein or protein-ligand interactions is a plus. Knowledge, theory behind and experience with protein expression, recombinant protein expression would be a plus.
  • Experience with Microsoft Excel, Prism, etc.

 

Education

  • BS/MS with strong interest in contributing to the discovery of PROTAC molecules with drug-like properties in an innovative Pharma/Biotech environment.
  • Training in biophysical techniques is a plus and will be provided as needed.

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Associate Scientist/ Sr. Associate Scientist, Biology (Strategic Collaborations)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts.

This position reports to a Senior Research Scientist/ Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and execute experiments, and perform data analysis
  • Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
  • Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
  • Execute protein expression and purification
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
  • Document, compile and interret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature

 

Qualifications

  • General knowledge of cancer biology
  • In vitro and or ex vivo tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Various bioassays (eg. Western blots, ELISA, multiplex protein analysis)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to work on several projects simultaneously.  Demonstrated ability to plan experiments independently a plus.
  • Proficiency in flow cytometry and data analysis a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

Education

  • BS with 8+ years experience or MS in Biology or relevant discipline with 3+ years experience

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Research Scientist/ Senior Research Scientist, Biology (Strategic Collaborations)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC®s (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC®-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

This key position is for a drug discovery and development project leader to support external partnership/ collaboration efforts across one or more diverse therapeutic areas.  The incumbent may supervise a small team of Research Associates.

This position reports to our Research Investigator, Biology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Develop compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Assay optimization to ensure quality and easily interpretable data is generated
  • Present data and project plans in project team meetings
  • Build strong alliances with external partners, focused on trust, collaboration, and timely/ high-quality delivery on shared objectives.

Qualifications

  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • A demonstrated ability to innovate and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy
  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • Broad scientific skillset with expertise in assay development, cell signaling, cell biology, and protein analysis
  • Demonstrable skill at building productive relationships with internal and external stakeholders at all levels, ability to influence and seek innovative solutions to complex scientific and strategic challenges.
  • Recruit, retain, and develop world-class scientific talent
  • Lead and participate on cross-disciplinary, drug discovery project teams; integrate and evaluate the work of a drug discovery group to determine optimal solutions to discovery challenges
  • Educate, support, coach, mentor, motivate, and grow scientists who are developing expertise in various therapeutic areas, in either a supervisory or matrix leadership capacity

Education

  • Ph.D, with 3+ years of productive post-doctoral fellowship experience or equivalent in biomedical research, cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential.
  • Strong publication record desired.

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Chemistry

MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC® (PROteolysis TArgeting Chimeras) protein degraders ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC® -based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

Clinical Development

Senior Director, Clinical Pharmacology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

Arvinas is searching for an agile and innovative Clinical Pharmacology leader to provide both day-to-day operational support and design pharmacology strategy on our high-priority development programs.  This critical role will collaborate closely with colleagues across the R&D organization and may select and direct internal and external teams of clinical pharmacology experts.  This role will work across diverse therapeutic areas and will be accountable for the delivery of clinical pharmacology and modeling and simulation strategy, delivery of PK and drug metabolism data from Phase I through Phase II/III of development, optimization of dosing regimens, and authoring relevant clinical and regulatory reports, documents, and publications.

This position reports to the Chief Medical Officer and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Design and implementation of Clinical Pharmacology plans for oncology and neuroscience drug development programs.
  • Provide Clinical Pharmacology representation on Drug Development Teams, providing clinical pharmacology input to the overarching clinical development plan.
  • Direct human clinical pharmacology trials, Phases I–IV, for programs under development.
  • Write clinical pharmacology portions of development protocols, clinical study reports, regulatory submission documents; contribute as required to relevant publications, and respond to regulatory questions related to clinical pharmacology.
  • Collaborate with preclinical scientists and pharmacologists, analyze translational models developed from preclinical data to predict human PK and develop efficacious dose projections.
  • Evaluate and perform hands-on analysis of clinical PK, safety and efficacy data and present clinical pharmacology results to internal and external stakeholders.
  • Utilize PK modeling to support dosing strategies for clinical programs.
  • Ensure quality of documentation for internal and external studies in compliance with global regulatory submission requirements

Qualifications

  • Expertise in PK/ PD, DM, DDI trials, and experience in developing clinical pharmacology plans for small molecules required.
  • Demonstrable expertise in interpreting and providing guidance on modeling and simulation activities applicable to PK and PD
  • Must have flexibility to work seamlessly across multiple development programs and provide pharmacology expertise across a diverse portfolio including multiple therapeutic areas.
  • Expertise in building and leading teams, including selection and management of key internal and external partners.  Experience overseeing external CROs in driving delivery of critical data very strongly preferred.
  • Excellent oral and written communication skills required.
  • Strong knowledge of drug development process; deep understanding of technical, business, and regulatory issues.
  • Demonstrated success in team leadership, with at least 3 years of management experience is preferred.

Education

  • MD, PharmD, or PhD with at least 10 years of bio/pharmaceutical industry drug development experience in clinical pharmacology.

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Senior Medical Director, Clinical Development

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

The Oncology Senior Medical Director will be a critical link with investigators and key opinion leaders in the external oncology community. He/She will work closely with these experts, developing the clinical trial strategy, designing clinical trials, and identifying appropriate investigators for the studies. This individual will serve as a key strategic and medical point person during the conduct of the trials, monitoring safety of ongoing trials and leading efforts to analyze and present data from clinical studies. The selected individual will work closely with other physicians, scientists, regulatory professionals, statisticians and members of the clinical operations department to carry out these responsibilities. The individual will respond to inquiries by practitioners and investigators, IRBs, regulatory bodies, and vendors. This person will work to establish relationships with key opinion leaders, external advisors and collaborators.  This position reports to our Chief Medical Officer and is located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Collaborate with physicians, scientists, regulatory professionals, biostatisticians, regulatory, executive staff and others as necessary for development of clinical development strategy and clinical protocols, and analysis of data from these trials and trials with other molecules.
  • In collaboration with ARVINAS clinical operations staff, consultants and CROs, support clinical trial execution to achieve timely completion of clinical studies.
  • Assume medical responsibility for clinical tria Actively participate in real-time medical monitoring of studies, including assessment of patient eligibility and responses to study design questions.
  • Provide safety monitoring in collaboration with CRO pharmacovigilance group of active clinical studies.
  • Collaborate with associates (and/or consultants) in Regulatory, CMC, Toxicology, Research, Pharmacology to progress clinical compounds from preclinical through Phase 1 – 3 clinical development, in a project team setting.
  • Participate in clinical study report writing and review, using his/her medical expertise to identify ways to best analyze and present data in a complete, accurate and scientifically sound manner.
  • Collaborate with Principal Investigators in the evaluation and assessment of publications (abstracts, posters, manuscripts) associated with clinical data.
  • Other responsibilities that may apply, as periodically assigned by his/her supervisor.

 

Qualifications

  • 5+ years of clinical development experience in solid tumor oncology.
  • Strong technical/analytical skills to identify and solve problems.
  • Self-motivated and confident with the ability to act with urgency and passion.
  • Proven ability to work with a high level of integrity, accuracy, and attention to detail.
  • Strong organizational skills in order to maintain a high level of productivity, innovation, and priority-setting in order to complete assignments on-time and on-budget.
  • Excellent oral and written communication skills for effectively interfacing with all levels of management and departments within the company.
  • Ability to make thoughtful, integrated, timely and meaningful decisions and take corresponding actions.
  • Willingness to work collaboratively by incorporating diverse perspectives and appropriately managing relationships in order to strength decision-making.
  • Proactively seeks out and recommends process improvements.
  • Resourceful, creative, enthusiastic, and results-oriented.
  • Entrepreneurial, enjoys working in a fast-paced, small-company environment.
  • Experience with managing or participating in breast oncology clinical
  • Successful academic research publication history or history of medical practice in a relevant
  • Experience presenting medical data and concepts to a variety of audiences (medical, scientific, vendors) in a credible and engaging manner.
  • Solid understanding of the clinical landscape relevant to oncology patients and health care practitioners in the
  • Daily user of Office tools (Word, Excel, PowerPoint, etc).
  • Demonstrated application of critical thinking skills to problem solving, data analysis, and strategic planning.
  • High degree of emotional Can work successfully in a demanding environment while constantly maintaining a professional demeanor.

 

Education

  • Doctor of Medicine degree (MD) or equivalent, MD/PhD pre

 

Please send CV and cover letter to: careers@arvinas.com.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

 

CMC

Manager/ Associate Director, Clinical Supplies

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTAC®s (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC®-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

The Supplies Manager is responsible for supporting the manufacture, forecasting, inventory management, labeling, packaging, and logistics of non-clinical and clinical supply requirements. This position works closely with Clinical Development Operations, API and DP Development, External Manufacturing, and Quality Assurance along with a variety of external CDMOs to implement the preclinical and clinical strategies for drug development programs and products.  The incumbent will serve as a core member of the development team and be the key contact for clinical supplies at Arvinas.  The incumbent will ensure that all activities occur in compliance with the appropriate SOPs and regulations.

This position reports to the Senior Director, CMC External Manufacturing and Supply and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Serve as the lead for the clinical supply planning, including demand forecasting. Manage supply planning and timelines to ensure alignment with study plans and timelines and the overall clinical development plan.
  • Responsible for working within established timelines of investigational product manufacturing, labeling, release, distribution and return/destruction, and/or helping to establish these timelines
  • Provide input to the development of IP-related study documents including protocols, study and pharmacy manuals
  • Oversee setup and management of IRT sytems e.g. IVRS and IWRS. Work with cross-functional teams to develop specifications and user testing of IRT systems provided by 3rd party vendors.
  • Manage and track investigational product (IP) inventory. Advise of potential shortages and make recommendations for resupply activities based on usage trends. Monitor and manage clinical supply activities through IRT, when appropriate, from study start-up through study closure.  Ensure appropriate system documentation is available for the TMF and inspection readiness.
  • Oversee IP shipment orders according to supply plans or as requested by the Clinical Development Operations team, to ensure timely and compliant shipment and delivery to investigator sites. Manage all aspects of the process.
  • Review and evaluate temperature excursion data with Formulation Development and Quality Assurance and communicates drug disposition to clinical trial managers, CROs, and investigator sites.
  • Review drug return and destruction records; communicates with investigator sites, CROs and external vendors to resolve issues.
  • Authorize final destruction of drug returns at 3rd party vendor.
  • Monitor IP expiry data and informs DP Manufacturing and Clinical Trial teams of pending IP expiry.
  • Assist in the preparation of RFPs, bid review, and contract content for packaging, labelling, and distribution.
  • As needed, assist the Sr. Director External Manufacturing and Supply in the preparation of RFPs, bid reviews, and contract content for API and DP development and supply.

Qualifications

  • Experience developing drug trial supply plans
  • Must possess Investigational Product forecasting skills
  • Experience in the development of specifications and testing of IRTs
  • A working knowledge of the drug development process and clinical trial methodology
  • Knowledge of ICH, GCP, GLP, GMP, and regulatory guidelines/directives
  • Knowledge of global clinical labeling requirements
  • Knowledge of Oncology and Neurodegenerative Disease areas are a plus.
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation and/or progression of a study and resolve the issues in a timely and creative fashion
  • Ability to effectively prioritize and deliver on tight timelines
  • Ability to multi-task and manage several projects in parallel, paying attention to detail
  • Ability to forge cross-functional working relationships with internal and external project partners
  • Good oral and written communications skills
  • Must have experience in using computers and databases for data collection, compilation, analysis, and information dissemination
  • Proficient with MS Word, PowerPoint, Excel

 

Education

  • BS/MS/PharmD and at least 6 years of relevant experience in the biotechnology/pharmaceutical industry, with 3 years minimum in clinical supply management

 

Please send CV and Cover Letter to Careers@Arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   


G & A


IT

Senior Engineer, IT Infrastructure and Operations

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

Arvinas is seeking a Senior Engineer to administer and provide operations services for its technical infrastructure.  This role works closely with the Vice President, Information Technology and the IT leadership team to provide expertise, implementation execution, and support for IT solutions that enhance mission-critical business operations. This position focuses on the data center and cloud services, hardware and operation, LAN/WAN networking, plus systems and data security both within and connecting to our infrastructure.  In addition, this role contributes to client end point management best practices and delivery of those supportive services and policies.  Collaborating with the Vice President, Information Technology and strategic IT partners, the Senior Engineer executes the IT service portfolios for each business unit/department and the service level agreements for the user community within the organization.

 

This position reports to the VP, Information Technology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Execute timely and consistent administration and operations responsibilities,
  • Deliver high-quality core infrastructure, and
  • Provide input to the IT team to develop network, server infrastructure, and operations systems.
  • Provide technical expertise in resolving both user system and infrastructure deficiencies.  Monitor and resolve support tickets for client end points and network, server, and storage infrastructure.
  • Create, monitor, and modify (as necessary) automated operations jobs to ensure success, completion, and adherence to stakeholder requirements, including backup jobs, system scans, and security and configuration change alerts.
  • Ensure infrastructure is up-to-date on all security and system patches and updates, including server operating systems, virus definitions, IT administrative applications, and infrastructure firmware.
  • Monitor system performance and security through creation of reports and dashboards.  Regularly review these with the Vice President, Information Technology.
  • Perform routine maintenance and configuration work as needed by the business (i.e., managing configurations on switches, setting up new client end point or laboratory instrument connections at drops and in wiring closets, troubleshooting connectivity issues, upgrading or installing new features in server operating systems, managing backup and replication jobs, creating new volumes or shares and installing hardware drives in storage infrastructure, etc.).
  • Ensure optimum network configuration and architecture for Arvinas’ evolving connectivity needs.  Work with IT partners to develop and execute best practices.
  • Perform analysis of system performance issues, makes modification of systems to increase operational efficiency, and reinstates system integrity as quickly as possible following an outage in order to minimize item and data loss.
  • Identify client end point management best practices, implements needed systems, scripts, and/or security policies, and manages end points throughout hardware and software lifecycle.
  • Recommend and authorizes system upgrades and software installations.
  • Research and recommends new system tools.
  • Maintain client end point and systems inventories, network topology diagrams, and service catalogs for systems and infrastructure.
  • Assist the Director, R&D systems with infrastructure setups for laboratory environments, including isolating research systems on VLANs, identifying opportunities and restrictions around antivirus and backup operations for instrument and analysis computers and executing identified plans, etc.
  • Collaborate with IT team and partners to identify opportunities to enhance, improve, and use new networking, server, or storage infrastructure.
  • Analyze execution time and success of operations activities to identify and remediate inefficient or ineffective tasks and scripts.
  • Analyze, evaluate, and act to circumvent problems and restore systems to operating condition.
  • Create system specifications and determines the combination of options needed to tailor operating systems and infrastructure configurations to meet the business needs.
  • Research new technologies, processes, and methodologies.
  • Provide accurate and on-time updates to team members, project managers, and management team.

 

Qualifications

  • 5+ years of related experience.
  • Advanced knowledge in computer systems and technologies, basic project management principles, and applicable laws and regulations as they relate to IT and the pharmaceutical industry.
  • Experience with the following software/ applications/ tasks is required:
    • VMWare vSphere and vCenter
    • Amazon Web Services and Azure/Azure AD
    • Microsoft technologies, including Active Directory, DNS, DHCP, certificate authorities, and fluency in PowerShell
    • Routing protocols and network monitoring protocols
    • Net gear, Cisco, and Dell network technologies
  • Experience with the following software/ applications/ tasks is preferred:
    • Vulnerability scanning, penetration testing, and disaster recovery
    • Linux administration skills
  • Excellent communication skills (oral and written), excellent interpersonal skills, excellent analytical and problem-solving skills, demonstrated ability to apply IT in solving business problems, strong negotiation skills, keen attention to detail, self-motivated and directed with a service orientation.
  • Ability to communicate complex network principles and server/storage concepts to non-technical and technical staff.
  • Ability to work independently.

 

Education

  • Four-year college degree (or equivalent knowledge gained through formal education, specialized training, or additional job experience).

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer