Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Associate Director/Director, Formulation R&D

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

We are currently seeking an experienced and strategic individual to lead CMC manufacturing and supply at Arvinas. The Director will serve as a core member of a multidisciplinary project team and directly impact strategy, timing, and execution of both drug substance and drug product development and manufacturing.  A key responsibility of this role will be technical oversight of the associated CDMOs.  The qualified individual will have a track record of accomplishment in preparing RFPs, CDMO selection, contracting, and CDMO oversight.   This position reports to our VP of CMC and will work closely with the heads of Chemical Process R&D and Formulation R&D.  In addition, the Director will work closely with project teams to develop and execute a streamlined program to advance assets into clinic and then into commercialization. The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

Primary Responsibilities

  • Provide technical expertise, and specialized knowledge in formulation development and drug product manufacturing to support the Arvinas portfolio of clinical drug assets.
  • Apply scientifically-driven thinking to the development of formulations and products which meet pre-determined product profiles.
  • Through the services of contract manufacturing vendors, maintain accountability for development, optimization, scale-up and technology transfer of scalable and robust processes applicable to oral and parenteral drug products.
  • Responsible for technical leadership in preparation of engineering, clinical, and validation batches.
  • Provide technical input on requests-for-proposals, identification of, and selection of vendors for scale-up and manufacture of clinical formulations.
  • Evaluate the activities and emergent data from on-going formulation development, manufacturing, and analytical work at CDMOs.
  • Evaluate data associated with characterization of drug products and stability testing and assess suitability of a drug product for an intended purpose.  Establish appropriate drug product specifications.
  • Convert data on formulations/products into knowledge required for IND and NDA filings. Assist in drafting the relevant sections of these regulatory filings.
  • Responsible for identifying drug product critical quality attributes
  • Responsible for effective risk assessments/FMEA for manufacturing processes
  • Interact effectively & build successful relationships with members of the Arvinas discovery, development, and project management staff.  Assist in creating efficient process development practices within Arvinas.

Qualifications

  • Minimum of a Master’s Degree in Chemistry, Pharmaceutics or Engineering
  • 10+ years of relevant experience in industrial drug development is required
  • Hands-on experience in formulation development, process optimization, scale-up, technology transfer, and manufacturing of solid oral and parenteral dosage forms of small molecules.
  • Must be experienced in managing early and late stage programs as a drug product lead
  • Familiarity with quality-by-design approaches to drug product development
  • Must be an experienced leader in a cross functional setting that requires frequent interaction with internal and external stakeholders relevant to early & late-stage product development.
  • Working knowledge of Good Manufacturing Practices (cGMPs) and Regulatory Guidance Documents as they relate to manufacture and quality testing of pharmaceutical products
  • Experience with creating RFPs, and working with CDMOs for formulation development, manufacturing of drug product, and analytical assays.
  • Ability to multi-task and manage several projects in parallel, and effectively prioritize and deliver on short timelines.
  • Proven ability to quickly adapt to changes in project direction
  • Ability to forge cross-functional working relationships with internal and external project partners
  • Excellent oral and written communications skills
  • Proven ability to think creatively, and obtain solutions to complex and diverse problems. Proven record of creative, productive, and insightful analysis and achievement.

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

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Assoc. Director/Director, CMC External Manufacturing & Supply

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

We are currently seeking an experienced and strategic individual to lead CMC manufacturing and supply at Arvinas. The Director will serve as a core member of a multidisciplinary project team and directly impact strategy, timing, and execution of both drug substance and drug product development and manufacturing.  A key responsibility of this role will be technical oversight of the associated CDMOs.  The qualified individual will have a track record of accomplishment in preparing RFPs, CDMO selection, contracting, and CDMO oversight.   This position reports to our VP of CMC and will work closely with the heads of Chemical Process R&D and Formulation R&D.  In addition, the Director will work closely with project teams to develop and execute a streamlined program to advance assets into clinic and then into commercialization. The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

Primary Responsibilities

  • Design, lead, and implement a comprehensive API and DP supply chain strategy at Arvinas.
  • Working with the heads of Process and Formulation R&D, craft and distribute request-for-proposals to CDMOs to access intermediate, API, and DP supplies to enable the Arvinas pipeline.
  • Evaluate proposals and quotes matching the capabilities of the supplier with the project requirements in terms of quantity, quality, and timing of deliverables.
  • Working with the heads of Process and Formulation R&D select the best providers of service to meet project needs.
  • Working with internal and external legal resources craft master service agreements and contracts to reflect required deliverables.
  • As the primary contact with the contractors, manage day-today interactions to ensure that deliverables are completed as contracted.
  • Contribute to technical oversight of contracted suppliers in execution of API and DP-related deliverables.
  • Drive forecast planning and inventory management of all intermediates, APIs, and DPs to meet near-term and long-term goals. Incorporate risk-mitigation strategies.
  • Lead budget-planning for API and DP campaigns and track all spend relative to budget.
  • Communicate production schedules to Project Management and the project team as part of project Integrated Development Plans for Arvinas assets.
  • Manage the CMC Supply Chain interfaces with Clinical Supply, Clinical Operations, Quality Assurance, and Regulatory Compliance.
  • Participate in strategy discussions to ensure that decisions align with agreed upon business direction and processes.
  • Lead the collection of relevant data and reports from suppliers to enable drafting of INDs, NDAs, and associated amendments.

Qualifications

  • A Ph.D in Chemistry, Pharmaceutics, or Chemical Engineering or related technical field and 10+ years relevant experience in CMC operational roles, preferably in a bio-tech environment.
  • A successful history of hands-on chemical, and/or formulation development and scale-up.
  • A successful track record in the RFP/contracting process along with detailed technical oversight of third-party contractors.
  • Experience with management of all stages API and DP development and manufacturing.
  • Comprehensive working knowledge of Good Manufacturing Practices (cGMPs) and regulatory guidance documents as they relate to manufacture and quality testing of pharmaceutical products.
  • Demonstrated experience in inventory management and forecasting.
  • Ability to effectively prioritize and deliver on tight timelines
  • Outstanding problem-solving abilities
  • Detail-oriented, with good organizational and project management skills
  • Good oral and written communications skills
  • Proficient with MS Word, PowerPoint, Excel
  • Strong leadership, project planning, negotiation and presentation skills
  • Significant experience in communicating/presenting complex information to senior management and regulatory agencies.
  • Ability to multi-task and manage several projects in parallel, paying attention to detail.
  • Ability to forge cross-functional working relationships with internal and external project partners
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective progression of an asset and resolve the issues in a timely and creative fashion

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

ASSOCIATE SYNTHETIC CHEMISTS (2)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the synthesis, purification and characterization of targeted PROTACTM protein degrader molecules in line with project, departmental and corporate timelines
  • Application of synthetic chemistry knowledge and skills to resolve bottleneck synthetic challenges and develop efficient synthetic routes to target molecules
  • Scale up of compounds in support of advanced pharmacological and toxicological studies
  • Coordination with external CRO resources to ensure best practices and synthetic approaches are employed to drive expeditious realization of targeted molecules

Functional Knowledge and Skills

  • Strong knowledge of traditional and contemporary synthetic chemistry-related scientific and technological principles and literature
  • Maintains accountability for ensuring own goals and those of any direct reports are achieved
  • Maintains orderly and timely record of experiments and results in accordance with company policy and legal requirements
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents as required
  • Maintains safe working environment for self and others
  • Ability to work safely with potentially hazardous chemicals
  • Experience with DNA encoded library techniques is a plus
  • Hands on experience with automated synthesis (combinatorial synthesis, DNA, peptide, liquid handler) techniques and equipment is a plus

Qualifications

  • A BS/MS synthetic chemist with >5 years of pharma/biotech-based experience
  • Proficiency with chemical drawing applications, database systems, and standard software packages such as Word, Excel, PowerPoint
  • Ability to summarize and transparently present work status in group settings
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner with peers and pan-disciplinary colleagues in a project setting

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

Senior Research Scientist/Research Investigator, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Qualifications

  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Strong expertise in cancer cell biology, drug discovery approaches and biochemical and biophysical techniques
  • Strength in running and evaluating experiments to measure target engagement, protein degradation, pathway modulation and therapeutic sensitivity in response to compounds
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Excellent communication and interpersonal skills

Education

  • Ph.D, with 3+ years of pharma- or biotech experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology
  • Focus on cancer biology, target validation, and drug discovery strongly preferred
  • Experience in immuno-oncology recommended, but not required

Other Preferred Skills and Knowledge

  • Manages times and balances work between bench and desk
  • Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved
  • Maintains a safe working environment for self and others
  • Represents the company effectively to external organizations and to the Board of Directors and other company senior management, as needed/requested
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

Sr. Research Investigator/Associate Director, DEL Chemistry

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

  • Design, synthesize, and analyze DNA Encoded Libraries (DELs)
  • Develop synthetic methods to enable novel DEL synthesis and/or to identify and implement innovative technologies
  • Analyze, interpret, and report experimental results at chemistry, program, and companywide meetings
  • Maintain detailed records of experiments in electronic lab notebooks in line with company policy
  • Contribute to conceptions, presentations, publications, and patents
  • Maintain a detailed knowledge of literature related to areas of research

Qualifications

  • Experience in Small Molecule Library Synthesis, Hit to Lead and/or Lead Optimization processes with strong interest in method development
  • Demonstrated ability to develop and follow multiple SAR treads for target/off-target potency and ADME optimization
  • Strong ability to design target molecules using both ligand and structure-based design principles
  • Experienced in using cheminformatics and other computational tools in drug design
  • Experience in purification and analytical methods (Preparative HPLC, SEC, LC/MS/MS, NMR)
  • Experience with operation, troubleshooting and maintenance of qTOF mass spectrometers and familiarity with automated liquid handlers is a plus
  • Ability to work effectively within a highly multidisciplinary team and experienced in collaborating across disciplines
  • Team spirit and excellent interpersonal skills
  • Ability to multitask while adhering to timelines
  • Self-motivated innovator with a focus on efficiency.
  • Excellent oral and written communication skills
  • Strong record of presentations, peer reviewed publications, and/or patents
  • Desire to lead initiatives in platform chemistry

Education

  • PhD in synthetic organic or medicinal chemistry with 5+ years medicinal chemistry experience in the pharmaceutical industry and 2+ years in DNA Encoded Library design and synthesis

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

Research Investigator/Sr. Research Investigator, Platform Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

Your focus will be to build innovative in vitro assay approaches to investigate mechanisms of protein degradation.  As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure that our platform technology evolves based on a rigorous scientific foundation.  Our aim is to further understand the underlying principles of PROTACs and continue to evolve our protein degradation platform in areas of high unmet medical need including cancer and neurodegeneration.

Principal Responsibilities

  • Application of strong expertise in molecular biology, cell biology, drug discovery approaches and biochemical and biophysical techniques to study PROTAC engagement of the ubiquitin proteasome system, or targeted protein degradation
  • Strength in executing and evaluating experiments to measure target engagement, protein degradation, pathway modulation and therapeutic sensitivity in response to compounds to develop structure-activity relationships
  • Experience in developing assays to profile compounds using mechanistic and functional readouts (intracellular binding approaches, bioluminescence (nanoBRET), fluorescence (FRET), High Content Imaging- a plus)
  • Strong expertise in molecular biology using siRNA/ ASOs, CRISPR knock out and mutagenesis strategies, and generation of relevant cell models to study targeted degradation in disease context.
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships
  • Excellent communication and interpersonal skills
  • Supervisory experience

Qualifications

  • PhD, with 5+ years of pharma/ biotech/ academic experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology. Focus on cancer cell biology and drug discovery strongly preferred.
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, preferred
  • Manages times and balances work between bench and desk
  • Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved
  • Proficient Data with data analysis tools (PRISM, Spotfire/Vortex, Matlab, etc. a plus)
  • Maintains a safe working environment for self and others
  • Represents the company effectively to external organizations and to the Board of Directors and other company senior management, as needed/requested
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents

Education

  • Ph.D.

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

Senior Research Scientist, Platform Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

 

Position Summary

Your focus will be to develop, implement and execute innovative in vitro assay approaches to investigate mechanisms of protein degradation.  As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure that our platform technology evolves based on a rigorous scientific foundation.  Our aim is to further understand the underlying principles of PROTACs and continue to evolve our protein degradation platform in areas of high unmet medical need including cancer and neurodegeneration.

 

Principal Responsibilities

  • Conducting key experiments aimed at elucidating mechanistic PROTAC engagement with components of the ubiquitin-proteasome system in cells
  • Strength in pharmacologic assessment of compounds in endogenous cell systems by assessing targeted degradation and pathway responses.
  • Experience in developing assays to profiling compounds for structure activity relationships using mechanistic, functional medium to high throughput readouts (High Content Image Analysis Quantification and Data reporting, ELISA, quantitative Western, High Content Imaging, Bioluminescent (nanoBRET) / Fluorescence assays, etc.)
  • Molecular techniques including cloning, qPCR, RT-PCR, cell line engineering using CRISPR/Cas9, is a plus
  • Recombinant cell line construction, Lentiviral infection of primary, cancer cell lines and iPSC a plus
  • Experience in utilizing compound inhibitors and molecular target manipulation (e.g. RNAi, CRISPR) to dissect target function and dependency

Qualifications

  • B.S./ M.S. with 12+ years or Ph.D. with 5+ years of pharma- or biotech experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology. Focus on cancer cell biology and drug discovery strongly preferred.
  • Experience studying the ubiquitin-proteasome system, or targeted protein degradation, preferred
  • Strong expertise in cell biology, drug discovery approaches, biochemical and biophysical techniques
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding.
  • Generate and maintaining clear experimental records.
  • Experience analyzing data using Microsoft Excel, Prism, Spotfire or Vortex or similar multiparametric analytical tool.
  • Excellent communication and interpersonal skills
  • Ability to mentor others
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved
  • Maintains a safe working environment for self and others
  • Contributes data/procedures/protocols for professional/technical reports as well as for scientific publications, patents and regulatory documents

Education

  • Ph.D. or B.S./M.S.

 

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Continue reading →

Senior Research Associate/Associate Scientist (Biology)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Education and Training

  • BS/MS with 4+ years of Pharma/Biotech drug discovery experience, or PhD with 2+ years of relevant experience

 

Required Skills and Abilities

  • Experience with biochemical and biophysical assay development, to evaluate compound SAR and characterize mode of action
  • Experience with fluorescence-based assay techniques (e.g. TR-FRET, AlphaLISA, FP, etc.) and label-free technologies (e.g. SPR, MST, etc.) is highly desired
  • A solid understanding of protein biochemistry and enzymology
  • Experience with protein expression and purification is preferred
  • High-throughput assay development and screening, plus experience with automated liquid handling instrumentation experience is also preferred
  • Strength in experimental design, execution, and data analysis
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious

 

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com

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Associate Scientist / Sr. Associate Scientist (Biology) (4)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

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Director/Senior Director, Project Leader, Biology

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Reports to: Vice President, Biology

 

Education and Training

  • PhD, with 15+ years of pharma or biotech drug discovery experience, preferably in oncology. Track record of leading research projects to IND-track nomination.

Position Summary

Responsible for the effective management of assigned therapeutic projects in line with company criteria and timelines within a matrix team environment, particularly in collaboration with partner Chemistry project lead

Provide transparent, focused updates to manager and company executives as requested and represent company at scientific conferences, regulatory body meetings and other external organizations as needed

May supervise/mentor junior PhD biologists

 

Requirements

  • Demonstrated success in leading a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong background in cancer biology and signaling with demonstrated expertise in incorporating this knowledge into drug discovery
  • Expertise in developing compound profiling mechanistic and functional assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection, specifically, running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD, safety & efficacy
  • Some bench work may be expected
  • Solid understanding of how to leverage biomarkers and translational research to guide clinical development
  • Contribute to regulatory documents, scientific publications, patents
  • Make scientific contributions that have significant impact on the Arvinas platform and overall research direction of the company
  • Maintain orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Accountability for ensuring own goals, those of any direct reports, project team goals, and project and company objectives are achieved
  • Excellent publication record
  • Maintain a safe working environment for self and others

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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Research Scientist/Sr. Research Scientist (Biology) (1)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential

Requirements

  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

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Sr. Associate Scientist/Research Scientist (Neurobiology)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. 

Arvinas is seeking a talented, innovative, and experienced biologist to investigate how targeted-protein degradation can impact neurodegenerative diseases. Successful candidates should be highly motivated and enjoy working in a team-based environment.

This position is laboratory-based and requires strong experimental skills with a background in cell biology, particularly with primary neuronal cultures, and experience in quantitative assay development, cell-based compound screening, biochemical assays, immunocytochemistry, and high-content imaging.

EDUCATION AND TRAINING:

  • BS/MS degree in neurobiology or related discipline
  • 8+ years Biotech/Pharma experience drug discovery experience in neuroscience

RESPONSIBILITIES INCLUDE:

  • Culture and maintenance of cell lines, primary neurons and iPSC-derived neurons
  • Stable cell line generation
  • Assessment of compound efficacy via immunocytochemical, biochemical and molecular biology techniques, such as immunostaining and immunoblotting
  • Interaction and collaboration with biology and chemistry team members to contribute to structure-activity relationship determination
  • Analysis of experimental data, addressing methodological problems in experimental protocols and results
  • Documentation, compilation, and interpretation of experimental data.
  • Presentation of data in oral and written reports in a clear and concise manner to supervisor and project teams
  • Management of laboratory notebook, databases and/or spreadsheets to compile and present results in a meaningful manner
  • Keeping up-to-date on relevant scientific literature

REQUIRED SKILLS AND ABILITIES:

  • Proficiency in basic lab techniques and principles of cell and molecular biology, biochemistry and neurobiology
  • Proficiency in culturing primary neurons and neuronal cell lines
  • Experience in assay validation, assay development and small molecule testing
  • Basic understanding of neurodegenerative diseases
  • Ability to work and problem-solve independently while under general supervision by the project leader

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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