Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Associate Chemist

As an associate chemist at Arvinas you will interact with a cross disciplinary research team aimed at the discovery and development of novel small molecule Proteolysis Targeting Chimeras (PROTACs) targeted towards multiple areas of unmet medical need. Your responsibilities will include planning, designing and executing multi-step synthetic sequences towards key molecules followed by purification, gathering of analytical data, and documenting your work in an electronic notebook. Participation in team meetings, internal presentations, contributing to documentation for external publications / presentations, and creative contributions to all areas of our PROTAC platform are essential.

Job Requirements and Responsibilities include:

  • BS or MS in Organic or Medicinal Chemistry with 5+ years experience in a laboratory setting
  • Extensive hands on experience with modern synthetic organic chemistry, and purification techniques including automated silica gel chromatography, preparative HPLC and crystallization techniques
  • A working knowledge of modern analytical techniques including NMR, MS, LC/MS and IR
  • The ability to troubleshoot and optimize organic reactions in a timely and independent manner
  • Familiarity with SciFinder and other literature searching engines
  • Making contributions to publications derived from project data
  • The ability to operate and maintain scientific laboratory equipment
  • Maintaining external awareness of scientific discipline through familiarity with current scientific literature
  • Attending technical staff and departmental meetings
  • Observance of appropriate safety and study requirements by reading, understanding and following Standard Operating Procedures (SOP) and study protocols
  • Knowledge of Microsoft Office Suites Products and chemical drawing programs including Chemdraw and Marvinsketch
  • A proven ability to work in a collaborative team environment

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

Research Scientist/Sr. Research Scientist (Biology)

Arvinas, a new start-up company based in New Haven, CT, is seeking innovative, collaborative and experienced biologists with expertise in cancer biology to investigate oncology biology as well as to develop novel, targeted therapeutics that address critical therapeutic targets to benefit patients suffering from cancer. Knowledge of the underpinnings of cancer therapeutic approaches is preferred but not essential. These positions require facility in working across disciplines to integrate the efforts of a project team to drive the discovery of novel small molecule therapeutics & deliver them for clinical testing.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential

Requirements

  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

Associate Scientist / Sr. Associate Scientist (Biology)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.