Careers

Careers at Arvinas

Open Positions

Arvinas, Inc. is seeking qualified candidates for the following open positions:

Associate Director, Project Management R&D

Key Responsibilities:

  • In partnership with team, drive and contribute to asset development team ensuring strategy and execution alignment
  • Develop, maintenance, proactive tracking and management of a high quality integrated project plans for multiple development projects
  • Facilitate discussions to drive towards program or initiative decisions
  • Identify, communicate and manage project and asset risks
  • Ability to conduct process analysis and develop and implement plans
  • Coordinate project team meeting and generate meeting minutes
  • Act as an interface with scientists to ensure smooth communication in internal programs as well as with external collaborators
  • Assists the development team responsible in the planning, implementation, and compliance of multiple aspects of Arvinas clinical trials using multiple vendors.
  • Willing to identify, development and/or implement forward thinking research and development initiatives to support company transformation

Qualifications:

  • Bachelor’s degree in Life Sciences or Pharmacy.
  • 8+ years in the pharmaceutical industry in roles associated with drug development
  • 5+ years supporting cross-functional drug development teams in core function
  • Must be able to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Superior communication and interpersonal skills; effective interaction with cross functional team members.
  • Experienced in managing multiple initiatives while working in a fast paced and dynamic environment.
  • Demonstrated planning, organization and time management skills including the ability to support and prioritize multiple projects.
  • Excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Skilled in managing multi-disciplinary teams both internally and externally
  • Flexibility in understand the needs of teams.
  • Proficiency with Project Management related and Microsoft Office Software Programs.
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Computational Design Chemist

Arvinas, the industry leader in protein degradation science is currently expanding its computational chemistry group with an additional hire to support the design and optimization of PROTACs, bifunctional, chimeric molecules that recruit target proteins to E3 ligases for ubiquitination and degradation by the cells natural and selective protein homeostasis system.

 

POSITION QUALIFICATIONS

The successful candidate should be an industry-experienced computational chemist with postdoctoral experience in molecular dynamics simulation, free energy perturbation calculation and/or conventional docking, and an understanding of basic medicinal chemistry.

Experience in protein modeling or protein-protein interaction modeling is a strong plus, and an ability in scripting, computer networking or cloud instance management is desirable.

An ability to effectively prioritize and deliver on tight timelines, plus good oral and written communications skills are a must.

Experience in using computers and databases for data collection, compilation, analysis, and information dissemination is also required, as is proficiency with MS Word, PowerPoint, and Excel.

 

LOCATION

New Haven, CT.

Suitably qualified candidates should send their resume plus a cover letter to careers@arvinas.com.

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Platform Biology, Leader

PhD-level position dedicated to conducting experiments to further understand the underlying principles of PROTAC-mediated protein degradation.

 

Education and Training

  • Ph.D, with 5+ years of pharma- or biotech experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology. Focus on cancer cell biology and drug discovery strongly preferred.

Requirements

  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding
  • Experience in the ubiquitin-proteasome system, or targeted protein degradation, preferred
  • Strong expertise in cancer cell biology, drug discovery approaches and biochemical and biophysical techniques
  • Strength in running and evaluating experiments to measure target engagement, protein degradation, pathway modulation and therapeutic sensitivity in response to compounds
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships
  • Excellent communication and interpersonal skills
  • Supervisory experience

Other Preferred Skills and Knowledge

  • Manages times and balances work between bench and desk
  • Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved
  • Maintains a safe working environment for self and others
  • Represents the company effectively to external organizations and to the Board of Directors and other company senior management, as needed/requested
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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Associate Scientist / Sr. Associate Scientist (Biology) (9)

Arvinas, a new start-up company in New Haven, CT, is seeking talented, innovative, and experienced biologists to investigate oncology target biology as well as to develop novel, targeted therapeutics that address the underlying genetic drivers of cancer. Successful candidates will participate in drug discovery teams that will develop both cell-mechanistic assays to probe target/pathway modulation and phenotypic assays to explore cell function.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • BS/MS with 8+ years of Pharma/Biotech drug discovery experience

Preferred Skills and Abilities

  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Strength in experimental design, execution, and data analysis
  • Organized, goal-oriented and timeline-conscious
  • Strength in leveraging multiple assay platforms for measuring target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
  • Experience in design, QC and execution of medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
  • Molecular techniques: cloning, PCR, RT-PCR, cell line engineering
  • Protein expression and purification

Experience in utilizing compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

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Director/Senior Director, Project Leader, Biology

Reports to: Vice President, Biology

 

Education and Training

  • PhD, with 15+ years of pharma or biotech drug discovery experience, preferably in oncology. Track record of leading research projects to IND-track nomination.

Position Summary

Responsible for the effective management of assigned therapeutic projects in line with company criteria and timelines within a matrix team environment, particularly in collaboration with partner Chemistry project lead

Provide transparent, focused updates to manager and company executives as requested and represent company at scientific conferences, regulatory body meetings and other external organizations as needed

May supervise/mentor junior PhD biologists

 

Requirements

  • Demonstrated success in leading a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong background in cancer biology and signaling with demonstrated expertise in incorporating this knowledge into drug discovery
  • Expertise in developing compound profiling mechanistic and functional assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection, specifically, running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD, safety & efficacy
  • Some bench work may be expected
  • Solid understanding of how to leverage biomarkers and translational research to guide clinical development
  • Contribute to regulatory documents, scientific publications, patents
  • Make scientific contributions that have significant impact on the Arvinas platform and overall research direction of the company
  • Maintain orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Accountability for ensuring own goals, those of any direct reports, project team goals, and project and company objectives are achieved
  • Excellent publication record
  • Maintain a safe working environment for self and others

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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Biology Lab Support

Arvinas, a fast-paced start-up biotech based in New Haven, CT, is seeking a highly organized, energetic, and proactive individual to support the Biology Department full time with the following:

  • General laboratory maintenance
    • Cleaning water baths
    • Defrosting freezers
    • Making buffers
    • Refilling carboys
    • Stocking consumables (flasks, pipette tips, tubes, etc.)
    • Washing glassware
    • Packaging biohazard waste
    • Emptying vacuum flasks
    • Monitoring equipment
  • Laboratory stock room management
    • Organizing laboratory stock room
    • Taking inventory and ordering items that are low
    • Stocking ordered items
  • Receiving
    • Processing delivered packages
    • Checking deliveries into accounting software
    • Delivering packages to recipient
  • Shipping for all company departments
    • Packaging and labeling box for shipping items
    • FedEx liaison
  • Biology Lab Activities
    • Tissue culture, eg passaging and harvesting cells
    • Gel electrophoresis
    • Western blots
    • ELISA

 

Minimum Education Requirement:  Associate’s Degree

Required Experience:  1-3 years in similar role, familiarity with biology lab activities, equipment and consumables, tissue culture, Office Suite, Windows Operating System

Preferred Experience: Great Plains accounting software

Suitably qualified candidates should send their resume and cover letter to careers@arvinas.com.

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Research Scientist/Sr. Research Scientist (Biology) (2)

Arvinas, a new start-up company based in New Haven, CT, is seeking innovative, collaborative and experienced biologists with expertise in cancer biology to investigate oncology biology as well as to develop novel, targeted therapeutics that address critical therapeutic targets to benefit patients suffering from cancer. Knowledge of the underpinnings of cancer therapeutic approaches is preferred but not essential. These positions require facility in working across disciplines to integrate the efforts of a project team to drive the discovery of novel small molecule therapeutics & deliver them for clinical testing.

Our Mission: To create a new class of drugs, which degrade pathogenic proteins as a way to treat diseases with serious unmet medical need and improve human health

Education and Training

  • Ph.D, with 3+ years of post-doctoral experience in cellular and molecular biology, pharmacology or enzymology. Focus on cancer cell biology and drug discovery preferred but not essential

Requirements

  • Innovative, motivated, researcher with strong problem solving and communication skills
  • Strong expertise in drug discovery approaches and scientific techniques
  • Strength in running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation

Preferred but Non-essential Requirements:

  • A Ph.D. or equivalent in biomedical research and a productive post-doctoral fellowship (at least 3 years) with a strong background in cancer biology and signaling and outstanding publications
  • Molecular-genetic understanding of cancer; facility incorporating this knowledge into drug discovery
  • Experience in developing assays to profile compounds using mechanistic and functional readouts
  • A demonstrated ability to be innovating and to advance new scientific understanding
  • Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
  • Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
  • Solid understanding of how to leverage biomarkers and translational research to guide development of personal medicine
  • Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

 

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Sr. Associate Scientist/Research Scientist (Neurobiology)

Arvinas LLC, a leading biotechnology company in New Haven, CT, is seeking a talented, innovative, and experienced biologist to investigate how targeted-protein degradation can impact neurodegenerative diseases. Successful candidates should be highly motivated and enjoy working in a team-based environment.

This position is laboratory-based and requires strong experimental skills with a background in cell biology, particularly with primary neuronal cultures, and experience in quantitative assay development, cell-based compound screening, biochemical assays, immunocytochemistry, and high-content imaging.

EDUCATION AND TRAINING:

  • BS/MS degree in neurobiology or related discipline
  • 8+ years Biotech/Pharma experience drug discovery experience in neuroscience

RESPONSIBILITIES INCLUDE:

  • Culture and maintenance of cell lines, primary neurons and iPSC-derived neurons
  • Stable cell line generation
  • Assessment of compound efficacy via immunocytochemical, biochemical and molecular biology techniques, such as immunostaining and immunoblotting
  • Interaction and collaboration with biology and chemistry team members to contribute to structure-activity relationship determination
  • Analysis of experimental data, addressing methodological problems in experimental protocols and results
  • Documentation, compilation, and interpretation of experimental data.
  • Presentation of data in oral and written reports in a clear and concise manner to supervisor and project teams
  • Management of laboratory notebook, databases and/or spreadsheets to compile and present results in a meaningful manner
  • Keeping up-to-date on relevant scientific literature

REQUIRED SKILLS AND ABILITIES:

  • Proficiency in basic lab techniques and principles of cell and molecular biology, biochemistry and neurobiology
  • Proficiency in culturing primary neurons and neuronal cell lines
  • Experience in assay validation, assay development and small molecule testing
  • Basic understanding of neurodegenerative diseases
  • Ability to work and problem-solve independently while under general supervision by the project leader

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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Sr. Associate/Research Scientist, Formulation R&D

The Research Scientist will serve as a core member of the development team and execute formulation strategy for Arvinas drug candidates. The incumbent will be responsible for executing exploratory research and development studies, as well as supporting clinical supply manufacture through in-house efforts and CDMOs. In addition, the successful candidate will support the in vivo group in preparing dosing solutions and troubleshooting vehicle failures.  He/She will work closely with in vivo biology, process chemistry, clinical supply logistics, and clinical to develop vehicles and formulation to advance assets into preclinical and clinical studies.  The incumbent will ensure all activities occur in compliance with the appropriate SOPs and regulations.

Responsibilities include research on and development of formulations to support enabling exploratory and pre-clinical animal studies, as well as clinical studies.  This will be accomplished through a blend of in-house and out-sourced activities.  In addition to a hands-on component, the incumbent will be responsible for preparing requests-for-proposals, and monitoring the activities of several formulation development and manufacturing organizations.  The incumbent will provide critical analysis of on-going development activities and continually assess the suitability of a particular formulation for its intended use. A key activity of this role will be the assembly/evaluation of pharmaceutical study data and drafting of the relevant sections of INDs and NDAs.

ESSENTIAL FUNCTIONS

  • Design, carry out, and interpret preformulation studies on new and potential drug candidates, with the purpose of defining their physicochemical and biopharmaceutical properties relevant to oral and parenteral administration
  • Develop fit-for-purpose formulations to enable exploratory and enabling animal studies
  • Provide technical expertise, and specialized knowledge in formulation development and drug product manufacturing to support the Arvinas portfolio of drug candidates.
  • Work closely with in-life groups to develop and prepare formulations suitable for use in drug discovery pharmacology, pharmacokinetic, and toxicology studies
  • Assist in the preparation of requests-for-proposals, selection of vendors, and monitoring the activities/emergent data of/from formulation development and manufacturing organizations.
  • Apply scientifically-driven thinking to the development of formulations and products which meet pre-determined product profiles.
  •  Evaluate data associated with characterization of drug products and stability testing and assess suitability of a drug product for an intended purpose.
  • Convert data on formulations/products into knowledge required for IND and NDA filings. Assist in drafting the relevant sections of these regulatory filings.
  • Works closely with peers on project teams to seamlessly and expeditiously advance Arvinas assets into the clinic

POSITION QUALIFICATIONS

  • BS/MS in Pharmaceutical / Medicinal / Physical / Analytical Chemistry
  • 6-10 years of experience in industrial drug development is required
  • Hands-on experience with formulation development/manufacturing
  • An understanding of basic medicinal chemistry and biopharmaceutical principles as they apply to drug discovery and development
  • A willingness to take on challenging problem statements and acquire/apply the skills necessary to address them
  • Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation and/or progression of a study and resolve the issues in a timely and creative fashion
  • Experience with creating RFPs, and working with CDMOs for pre-formulation, formulation development, and manufacturing of drug product
  • Working knowledge of Good Manufacturing Practices (cGMPs) and Regulatory Guidance Documents as they relate to manufacture and quality testing of pharmaceutical products
  • Ability to effectively prioritize and deliver on tight timelines
  • Experience in communicating/presenting complex information to senior management
  • Ability to multi-task and manage several projects in parallel, paying attention to detail
  • Ability to forge cross-functional working relationships with internal and external project partners
  • Good oral and written communications skills
  • Experience in using computers and databases for data collection, compilation, analysis, and information dissemination
  • Proficient with MS Word, PowerPoint, Excel

Job Requirements – Personality

 

  • Conduct themselves in an ethical, honest and accountable manner
  • Ability to establish and maintain effective working relationships
  • Ability to work in a fast-paced, highly-motivated work environment
  • Entrepreneurial with self-starting personality; ability to prioritize and manage multiple responsibilities simultaneously
  • Enthusiastic desire to roll up sleeves and dig in. Confidence in own abilities to get things done.
  • Able to meet tight deadlines on multiple priorities.
  • Strong analytical skills with attention to detail and accuracy
  • Customer focused with strong team work, interpersonal and communication skills
  • Requirement to maintain a high level of confidentiality
  • Ability to develop solutions to problems and implement them.

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com.

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