Arvinas is committed to expanding its transformative degradation platform and moving important new therapies into clinical development, and we would welcome discussions on meaningful strategic collaborations.
Our interest in collaborating is to expand the universe of druggable targets with our transformative protein degradation technology.
Opportunities for platform and product deals, include the following:
- Targets of interest to Arvinas
- Targets of interest to partner
- Targets with ligands with suboptimal affinity
- Targets with ligands without function
- Targets with nontraditional binding ligand
You can contact us at BD@arvinas.com.
Arvinas has significant partnerships with Genentech and Pfizer, two of the leading research and development organizations in the industry. We believe their interest in protein degradation as a therapeutic approach to address difficult disease targets offers an exciting opportunity to explore the full potential of PROTACTM protein degraders to harness the body’s ability to degrade disease-causing proteins.
In November 2017, Arvinas and Genentech, a member of the Roche Group, expanded their multi-year strategic license agreement to encompass additional disease targets. The collaboration was formed in October 2015 to develop new therapeutics using Arvinas’ PROTAC® technology platform.
As part of the expansion, Arvinas is now eligible to receive more than $650 million in development and commercialization milestones as well as tiered royalties on sales of products. Genentech has the option to further expand the collaboration to include other disease targets for consideration.
In January 2018, Arvinas announced a research and collaboration license agreement with Pfizer Inc. for the discovery and development of drug candidates using Arvinas’ PROTAC® technology platform, which is designed to degrade harmful target proteins. The multi-year collaboration covers multiple disease targets across several therapeutic areas.
Arvinas may receive up to $830 million in upfront and potential development and commercialization milestone payments in addition to tiered royalties. Arvinas will drive discovery efforts, while Pfizer will be accountable for clinical development and commercialization of any products that may result from the collaboration.