Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit

Primary Responsibilities

  • Responsible for the synthesis, purification and characterization of targeted PROTACTM protein degrader molecules in line with project, departmental and corporate timelines
  • Application of synthetic chemistry knowledge and skills to resolve bottleneck synthetic challenges and develop efficient synthetic routes to target molecules
  • Scale up of compounds in support of advanced pharmacological and toxicological studies
  • Coordination with external CRO resources to ensure best practices and synthetic approaches are employed to drive expeditious realization of targeted molecules

Functional Knowledge and Skills

  • Strong knowledge of traditional and contemporary synthetic chemistry-related scientific and technological principles and literature
  • Maintains accountability for ensuring own goals and those of any direct reports are achieved
  • Maintains orderly and timely record of experiments and results in accordance with company policy and legal requirements
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents as required
  • Maintains safe working environment for self and others
  • Ability to work safely with potentially hazardous chemicals
  • Experience with DNA encoded library techniques is a plus
  • Hands on experience with automated synthesis (combinatorial synthesis, DNA, peptide, liquid handler) techniques and equipment is a plus


  • A BS/MS synthetic chemist with >5 years of pharma/biotech-based experience
  • Proficiency with chemical drawing applications, database systems, and standard software packages such as Word, Excel, PowerPoint
  • Ability to summarize and transparently present work status in group settings
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner with peers and pan-disciplinary colleagues in a project setting

Please send CV and cover letter to:

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity employer