Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.
Reports to: Vice President, Biology
Education and Training
- PhD, with 15+ years of pharma or biotech drug discovery experience, preferably in oncology. Track record of leading research projects to IND-track nomination.
Responsible for the effective management of assigned therapeutic projects in line with company criteria and timelines within a matrix team environment, particularly in collaboration with partner Chemistry project lead
Provide transparent, focused updates to manager and company executives as requested and represent company at scientific conferences, regulatory body meetings and other external organizations as needed
May supervise/mentor junior PhD biologists
- Demonstrated success in leading a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
- Innovative, motivated, researcher with strong problem solving and communication skills
- Strong background in cancer biology and signaling with demonstrated expertise in incorporating this knowledge into drug discovery
- Expertise in developing compound profiling mechanistic and functional assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection, specifically, running and evaluating experiments to measure target engagement, pathway modulation and therapeutic sensitivity in response to compounds or target modulation
- Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD, safety & efficacy
- Some bench work may be expected
- Solid understanding of how to leverage biomarkers and translational research to guide clinical development
- Contribute to regulatory documents, scientific publications, patents
- Make scientific contributions that have significant impact on the Arvinas platform and overall research direction of the company
- Maintain orderly and timely record of project plans and results in accordance with company policy and legal requirements
- Accountability for ensuring own goals, those of any direct reports, project team goals, and project and company objectives are achieved
- Excellent publication record
- Maintain a safe working environment for self and others
New Haven, CT
Please send CV and cover letter to: email@example.com.