MEDICINAL CHEMISTRY PROJECT LEADER

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM (PROteolysis TArgeting Chimera) protein degrader molecules ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Primary Responsibilities

  • Responsible for the effective management of assigned therapeutic or platform PROTACTM projects in line with target project profiles and timelines within a team environment
  • Requires the expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
  • Requires a dynamic interaction with external CRO resources to ensure synthetic and data needs are fulfilled according to agreed timelines and standards
  • Requires solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp-decision making within the project environment to meet company, project and personal goals and timelines
  • Ensures that key program progression compounds and data are being generated and decision-making based on strong scientific judgment is occurring.
  • Responsible for providing considered and focused input across all phases of drug discovery, smoothly collaborates with other functions in drug discovery, and exemplifies leadership, demanding excellence in performance at all levels
  • As required to meet goals, personally executes on synthetic routes to pioneer chemistry and address recalcitrant key project molecules and intermediates
  • Provides transparent and coherent and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed

Functional Knowledge and Skills

  • Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
  • Manages time and balances work between bench and desk; completes tasks in timely manner
  • Manages a group of external scientists
  • Maintains accountability for ensuring own goals, those of any direct reports, project team goals, project and company objectives are achieved
  • Represents research/project team at high level meetings within the company
  • Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
  • Makes broad scientific contributions that have a positive impact on the research direction of the company
  • Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
  • Represents the company effectively in scientific matters to external organizations
  • Maintains safe working environment for self and others

Qualifications

  • A PhD synthetic/medicinal chemist with 4-10 years of pharma/biotech-based drug discovery experience, with a track-record of leading/contributing to research projects towards IND-track nomination
  • A track record of creative contributions to drug design, especially structure-based design, optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
  • A strong patent and publication record evidencing scientific curiosity and strong communication skills
  • Proficiency with database mining, graphing and interpretation
  • A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas

Please send CV and cover letter to: careers@arvinas.com

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer