Research Associate Platform Biology (Biophysics)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Position Summary

We are looking for a scientist to strengthen our biophysics team. This position will directly use biophysical and biochemical methods to characterize the binding of ligands for transformation into PROTACs. This position will provide the key, critical data necessary to drive programs toward targeted degradation.

This position reports to the Senior Associate Scientist in our Platform Biology group and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Utilization of assay design techniques, quality control and execution of medium- to high- throughput 96/384 well assay formats, such as SPR, MST, AlphaLISA, quantitative Bioluminescent/ Fluorescence assays, and other biophysical/biochemical approaches
  • Incumbent will also learn how to apply biophysical techniques to PROTAC discovery through determination of binding affinities, binding kinetics and protein-protein interactions
  • Leverage and think about principles behind multiple assay platforms for measuring target engagement, biophysical approaches including SPR, MST, TR-FRET, AlphaLISA, and apply them to the ubiquitin-proteasome system and targeted protein degradation
  • Apply excellent organizational and prioritization skills; demonstrate accomplished biologic and biochemical academic record with laboratory experience.  Analyze data using strong background in quantitative sciences.
  • Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs.  Troubleshoot through technical and scientific challenges in order to deliver critical data.
  • Organize experimental results to be shared with project teams; openly communicate with chemistry; maintain clear experimental records.

 

Qualifications

  • A strong work ethic and willingness to learn drug discovery approaches and biochemical and biophysical techniques, is a requirement. Strong theoretical knowledge in biophysics and biochemistry is a plus.
  • Knowledge and theory behind protein expression, recombinant protein expression would be a plus
  • Experience with Microsoft Excel, Prism, etc.

 

Education

  • BS/MS with strong interest in contributing to the discovery of PROTAC molecules with drug-like properties in an innovative Pharma/Biotech environment.  Training in biophysical techniques is a plus and will be provided as needed.

Please send CV and cover letter to: careers@arvinas.com

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer