Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.
Arvinas is seeking an innovative and collaborative biologist with expertise in prostate cancer biology. The candidate should be knowledgeable about the Androgen Receptor (AR) biology and experimental techniques employed to study nuclear hormone receptor signaling. The responsibilities involve conducting mode of action studies with existing and novel AR PROTACs. The ability to conduct and oversee in vivo prostate cancer model development is recommended.
EDUCATION AND TRAINING
Ph.D, with 0-3 years of post-doctoral experience in cellular and molecular biology, pharmacology or biochemistry. Previous experience in prostate cancer research is required.
- Culture and maintenance of cell lines, including generation of stable cell lines
- Assessment of compound efficacy via biochemical and molecular biology techniques, such as immunostaining and immunoblotting (e.g. high content imaging, western, qPCR, reporter assay)
- Interaction and collaboration with biology and chemistry team members to contribute to structure-activity relationship (SAR) determination
- Solving methodological problems in experimental protocols and results
- Documentation, compilation, analysis and interpretation of experimental data
- Presentation of data in oral and written reports in a clear and concise manner to supervisor and project teams
- Management of laboratory notebook, databases and/or spreadsheets to compile and present results in a meaningful manner
- Staying up-to-date on relevant scientific literature
- Innovative, motivated, researcher with strong problem solving and communication skills
- Expertise in cell-based assays to study nuclear hormone receptor signaling
- Demonstrated subject matter expertise via publications and/or external presentations
PREFERRED BUT NON-ESSENTIAL REQUIREMENTS:
- Experience in developing novel assays and animal models in prostate cancer
- Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions
- Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships that guide lead identification, optimization & development candidate selection
- Solid understanding of how to leverage biomarkers and translational research to guide development of personalized medicine
- Knowledge of assays & metrics that report on potency, selectivity, ADME, PK, PD & efficacy
Location: New Haven, CT
Please send CV and cover letter to: firstname.lastname@example.org. Please denote in the subject line the specific position: AR/Prostate Cancer