Senior Research Associate/Associate Scientist (Biology)

Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACTM protein degraders (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets.

Education and Training

  • BS/MS with 4+ years of Pharma/Biotech drug discovery experience

 

Required Skills and Abilities

  • Experience with biochemical and biophysical assay development, to evaluate compound SAR and characterize mode of action
  • Experience with fluorescence-based assay techniques (e.g. TR-FRET, AlphaLISA, FP, etc.) and label-free technologies (e.g. SPR, MST, etc.) is highly desired
  • A solid understanding of protein biochemistry and enzymology
  • Experience with protein expression and purification is preferred
  • High-throughput assay development and screening, plus experience with automated liquid handling instrumentation experience is also preferred
  • Strength in experimental design, execution, and data analysis
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious

 

Location

New Haven, CT

Please send CV and cover letter to: careers@arvinas.com