Sr. Associate Scientist/Research Scientist (Neurobiology)

Arvinas LLC, a leading biotechnology company in New Haven, CT, is seeking a talented, innovative, and experienced biologist to investigate how targeted-protein degradation can impact neurodegenerative diseases. Successful candidates should be highly motivated and enjoy working in a team-based environment.

This position is laboratory-based and requires strong experimental skills with a background in cell biology, particularly with primary neuronal cultures, and experience in quantitative assay development, cell-based compound screening, biochemical assays, immunocytochemistry, and high-content imaging.

EDUCATION AND TRAINING:

  • BS/MS degree in neurobiology or related discipline
  • 8+ years Biotech/Pharma experience drug discovery experience in neuroscience

RESPONSIBILITIES INCLUDE:

  • Culture and maintenance of cell lines, primary neurons and iPSC-derived neurons
  • Stable cell line generation
  • Assessment of compound efficacy via immunocytochemical, biochemical and molecular biology techniques, such as immunostaining and immunoblotting
  • Interaction and collaboration with biology and chemistry team members to contribute to structure-activity relationship determination
  • Analysis of experimental data, addressing methodological problems in experimental protocols and results
  • Documentation, compilation, and interpretation of experimental data.
  • Presentation of data in oral and written reports in a clear and concise manner to supervisor and project teams
  • Management of laboratory notebook, databases and/or spreadsheets to compile and present results in a meaningful manner
  • Keeping up-to-date on relevant scientific literature

REQUIRED SKILLS AND ABILITIES:

  • Proficiency in basic lab techniques and principles of cell and molecular biology, biochemistry and neurobiology
  • Proficiency in culturing primary neurons and neuronal cell lines
  • Experience in assay validation, assay development and small molecule testing
  • Basic understanding of neurodegenerative diseases
  • Ability to work and problem-solve independently while under general supervision by the project leader

Location

New Haven, CT

Please send CV and cover letter to:Ā careers@arvinas.com.