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NEW HAVEN, Conn., November 29, 2016 – Arvinas LLC, a private biotechnology company creating a new class of drugs based on protein degradation, today announced that data were presented by Dr. Kevin Coleman, Vice President of Exploratory Biology, during an oral presentation at the 28th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium being held November 28 – December 2, 2016, in Munich, Germany.
“The data presented today support the ongoing work from our research team in building out a new paradigm in medicine with the PROTAC platform. We believe that protein degradation confers key mechanistic benefits over inhibition leading to efficacy improvements, and these data further show this, where the intermittent IV dosing of our BET PROTAC leads to potential safety improvements over BET inhibitors,” said Manuel Litchman, M.D., President and CEO of Arvinas.
Highlights from the data presented today include:
This presentation was part of Plenary Session 1, “Degradation Based Therapeutics,” which was co-chaired by Dr. Craig M. Crews, Lewis B. Cullman Professor of Molecular, Cellular and Developmental Biology at Yale University, and Arvinas Founder and Chief Scientific Advisor.
Dr. Coleman’s presentation is available on the Arvinas website under Publications at www.arvinas.com.
Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins. Based on groundbreaking research conducted at Yale University by Founder and Chief Scientific Advisor, Dr. Craig Crews, the company is translating innovative protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The company’s new PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, and offers the advantage of potentially targeting “undruggable” as well as “druggable” elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.
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