Therapeutic Programs

therapeutic programs

Pipeline

ProgramStage of Development

Indication

Target

Discovery

Lead Optimization

IND Enabling

Phase 1

Phase 2

Phase 3

Anticipated Milestones

Oncology

Metastatic Castration-Resistant Prostate Cancer

ARV-110AR
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3
  • IND Filing: 2H18
  • Initiate Ph. 1: 1Q19
  • Preliminary Data: 2H19
Next Generation DegraderAR
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3
AR Variant DegraderAR-V7
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3

Metastatic ER+ Breast Cancer

ARV-471ER
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3
  • IND Filing: 1H19
  • Initiate Ph. 1: Mid 2019
  • Preliminary Data: 2020

Additional Oncology Indications

CRC, NSCLCUndisclosed
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3
Central Nervous System

Tauopathies

Alzheimer’sTau
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3

Other Neurodegenerative Diseases

Parkinson’sα-Synuclein
DiscoveryLead OptimizationIND-EnablingPhase 1Phase 2Phase 3